P23 Antibody (JJ6): sc-101496

P23 Antibody (JJ6) is a mouse monoclonal IgG2b kappa light chain antibody that detects P23 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). P23 (JJ6) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. P23, also known as PTGES3 (prostaglandin E synthase 3) or TEBP (telomerase-binding protein p23), is a crucial cochaperone that is ubiquitously expressed and plays a significant role in cellular signal transduction. One of P23′s key functions is to assist in the proper folding and activation of steroid hormone receptors, particularly estrogen receptor alpha (ERα), which is vital for regulating gene expression related to hormonal responses. P23 is localized in the cytoplasm, where P23 interacts with the glucocorticoid receptor (GR) and is believed to inhibit GR-dependent transcription by disrupting the transcriptional machinery. This interaction highlights P23′s importance in modulating steroid receptor-mediated pathways, which are essential for various cellular processes. Furthermore, P23 upregulation has been linked to the invasion and metastasis of several cancers, underscoring P23′s potential as a biomarker and therapeutic target in oncology.

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P23 Antibody (JJ6) References:

1. The identification of Wos2, a p23 homologue that interacts with Wee1 and Cdc2 in the mitotic control of fission yeasts.  |  Muñoz, MJ., et al. 1999. Genetics. 153: 1561-72. PMID: 10581266
2. Disassembly of transcriptional regulatory complexes by molecular chaperones.  |  Freeman, BC. and Yamamoto, KR. 2002. Science. 296: 2232-5. PMID: 12077419
3. Regulation of cytosolic prostaglandin E2 synthase by 90-kDa heat shock protein.  |  Tanioka, T., et al. 2003. Biochem Biophys Res Commun. 303: 1018-23. PMID: 12684036
4. p23, a simple protein with complex activities.  |  Felts, SJ. and Toft, DO. 2003. Cell Stress Chaperones. 8: 108-13. PMID: 14627195
5. Caspase-dependent, geldanamycin-enhanced cleavage of co-chaperone p23 in leukemic apoptosis.  |  Gausdal, G., et al. 2004. Leukemia. 18: 1989-96. PMID: 15483679
6. The co-chaperone p23 is degraded by caspases and the proteasome during apoptosis.  |  Mollerup, J. and Berchtold, MW. 2005. FEBS Lett. 579: 4187-92. PMID: 16038904
7. Intracellular dynamics of the Hsp90 co-chaperone p23 is dictated by Hsp90.  |  Picard, D. 2006. Exp Cell Res. 312: 198-204. PMID: 16289154
8. The cochaperone p23 differentially regulates estrogen receptor target genes and promotes tumor cell adhesion and invasion.  |  Oxelmark, E., et al. 2006. Mol Cell Biol. 26: 5205-13. PMID: 16809759
9. The Hsp90 cochaperone p23 is essential for perinatal survival.  |  Grad, I., et al. 2006. Mol Cell Biol. 26: 8976-83. PMID: 17000766
10. The co-chaperone p23 promotes prostate cancer motility and metastasis.  |  Cano, LQ., et al. 2015. Mol Oncol. 9: 295-308. PMID: 25241147
11. P23 Acts as Functional RBP in the Macrophage Inflammation Response.  |  de Vries, S., et al. 2021. Front Mol Biosci. 8: 625608. PMID: 34179071
12. The p23 co-chaperone is a succinate-activated COX-2 transcription factor in lung adenocarcinoma tumorigenesis.  |  Yu, Z., et al. 2023. Sci Adv. 9: eade0387. PMID: 37390202

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-P23 Antibody (JJ6) has 4 citations in a variety of scientific publications.

Primary antibodies like Anti-P23 Antibody (JJ6) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

P23 Antibody (JJ6) Specifications

Alternate Product Name: P23

Product Clone Name: JJ6

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b kappa light chain

Amino Acids:

Epitope Target: P23

Epitope Species: human

Product Reactivity/Detection: P23

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG_2b kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 4 citations in various scientific publications

Available Conjugates/Forms for P23 Antibody (JJ6): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin