P23 Antibody (B-5): sc-377392

P23 Antibody (B-5) is a mouse monoclonal IgG1 antibody that detects P23 in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). P23, also known as PTGES3 (prostaglandin E synthase 3) or TEBP (telomerase-binding protein p23), is a ubiquitously expressed protein that serves as a cochaperone within the HSP 90-based molecular chaperone complex, playing a crucial role in signal transduction. P23 is primarily located in the cytoplasm, where P23 interacts with key steroid hormone receptors, including the glucocorticoid receptor (GR) and estrogen receptor alpha (ERα). P23 interaction with these receptors is vital for the regulation of transcriptional activity, as P23 facilitates the maturation of ERα and modulates GR-dependent transcription by disassembling the GR transcription machinery. P23 influence on these pathways underscores P23′s importance in cellular processes and signal transduction, particularly in hormone signaling. P23 upregulation has been linked to the invasion and metastasis of various cancers, highlighting P23′s potential as a biomarker and therapeutic target in oncology.

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P23 Antibody (B-5) References:

1. Genetic dissection of p23, an Hsp90 cochaperone, reveals a distinct surface involved in estrogen receptor signaling.  |  Oxelmark, E., et al. 2003. J Biol Chem. 278: 36547-55. PMID: 12835317
2. The co-chaperone p23 arrests the Hsp90 ATPase cycle to trap client proteins.  |  McLaughlin, SH., et al. 2006. J Mol Biol. 356: 746-58. PMID: 16403413
3. The cochaperone p23 differentially regulates estrogen receptor target genes and promotes tumor cell adhesion and invasion.  |  Oxelmark, E., et al. 2006. Mol Cell Biol. 26: 5205-13. PMID: 16809759
4. A subset of p23 localized on secretory granules in pancreatic beta-cells.  |  Hosaka, M., et al. 2007. J Histochem Cytochem. 55: 235-45. PMID: 17101722
5. Knockout mice lacking cPGES/p23, a constitutively expressed PGE2 synthetic enzyme, are peri-natally lethal.  |  Nakatani, Y., et al. 2007. Biochem Biophys Res Commun. 362: 387-92. PMID: 17719010
6. The role of p23, Hop, immunophilins, and other co-chaperones in regulating Hsp90 function.  |  Cox, MB. and Johnson, JL. 2011. Methods Mol Biol. 787: 45-66. PMID: 21898226
7. An Erythrocytosis-Associated Mutation in the Zinc Finger of PHD2 Provides Insights into Its Binding of p23.  |  Song, D., et al. 2019. Hypoxia (Auckl). 7: 81-86. PMID: 31853455
8. Ailanthus Altissima-derived Ailanthone enhances Gastric Cancer Cell Apoptosis by Inducing the Repression of Base Excision Repair by Downregulating p23 Expression.  |  Wang, CM., et al. 2021. Int J Biol Sci. 17: 2811-2825. PMID: 34345209
9. Binding of p23 and hsp90 during assembly with the progesterone receptor.  |  Johnson, JL. and Toft, DO. 1995. Mol Endocrinol. 9: 670-8. PMID: 8592513
10. Involvement of the transmembrane protein p23 in biosynthetic protein transport.  |  Rojo, M., et al. 1997. J Cell Biol. 139: 1119-35. PMID: 9382861

The preferred P23 antibody is P23 Antibody (JJ6): sc-101496.