CDKN2A/p16 Antibody (G-6): sc-74400
- CDKN2A/p16 Antibody (G-6) is a mouse monoclonal IgG2a, cited in 4 publications, provided at 200 µg/ml
- raised against amino acids 1-168 representing full length p16 INK4A of mouse origin
- recommended for detection of p16 INK4A of mouse and human origin by WB, IP, IF and ELISA
- m-IgG Fc BP-HRP, m-IgG2a BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for CDKN2A/p16 Antibody (G-6) for WB applications. These reagents are now offered in bundles with CDKN2A/p16 Antibody (G-6) (see ordering information below).
p16 INK4A Antibody (G-6) is a mouse monoclonal IgG2a antibody that detects p16 INK4A in mouse and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). p16 INK4A plays a crucial role as a negative regulator of the cell cycle, specifically inhibiting cyclin-dependent kinase 4 (Cdk4) activity, which is essential for the transition from the G1 phase to the S phase of the cell cycle. By binding to Cdk4, p16 INK4A prevents the formation of the active Cdk4/cyclin D complex, thereby halting cell proliferation and serving as a critical tumor suppressor. Frequent mutations and homozygous deletions of p16 INK4A observed in various human tumor cell lines underscore p16 INK4A′s significance in cancer biology and potential for therapeutic targeting. Anti-p16 INK4A antibody (G-6) serves as an invaluable tool for researchers studying cell cycle regulation and molecular mechanisms underlying tumorigenesis.
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Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CDKN2A/p16 Antibody (G-6) | sc-74400 | 200 µg/ml | $322.00 | |||
CDKN2A/p16INK4a Antibody (G-6): m-IgG Fc BP-HRP Bundle | sc-537227 | 200 µg Ab; 10 µg BP | $361.00 | |||
CDKN2A/p16INK4a Antibody (G-6): m-IgGκ BP-HRP Bundle | sc-534440 | 200 µg Ab; 40 µg BP | $361.00 | |||
CDKN2A/p16INK4a Antibody (G-6): m-IgG2a BP-HRP Bundle | sc-547944 | 200 µg Ab; 10 µg BP | $361.00 |