CDKN2A/p16 Antibody (F-8): sc-373695
- CDKN2A/p16 Antibody (F-8) is a mouse monoclonal IgG2a, cited in 6 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 4-31 at the N-terminus of p16 INK4A of human origin
- recommended for detection of p16 INK4A of human origin by WB, IP, IF and ELISA
- m-IgG Fc BP-HRP, m-IgG2a BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for CDKN2A/p16 Antibody (F-8) for WB applications. These reagents are now offered in bundles with CDKN2A/p16 Antibody (F-8) (see ordering information below).
p16 INK4A Antibody (F-8) is a mouse monoclonal IgG2a antibody that detects p16 INK4A in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). p16 INK4A plays a crucial role as a tumor suppressor by inhibiting cyclin-dependent kinase 4 (Cdk4), thereby preventing the phosphorylation of the retinoblastoma protein (Rb) and blocking cell cycle progression from the G1 phase to the S phase. This function is vital for maintaining proper cell cycle regulation and preventing uncontrolled cell proliferation, which is a hallmark of cancer. p16 INK4A frequently undergoes homozygous deletions and point mutations in various human tumor cell lines, leading to the loss of inhibitory function and contributing to tumorigenesis. anti-p16 INK4A antibody (F-8) serves as an essential tool for researchers studying cell cycle regulation and the molecular mechanisms underlying cancer development, providing insights into cellular processes.
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Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CDKN2A/p16 Antibody (F-8) | sc-373695 | 200 µg/ml | $322.00 | |||
CDKN2A/p16INK4a Antibody (F-8): m-IgG Fc BP-HRP Bundle | sc-537864 | 200 µg Ab; 10 µg BP | $361.00 | |||
CDKN2A/p16INK4a Antibody (F-8): m-IgGκ BP-HRP Bundle | sc-535298 | 200 µg Ab; 40 µg BP | $361.00 | |||
CDKN2A/p16INK4a Antibody (F-8): m-IgG2a BP-HRP Bundle | sc-548132 | 200 µg Ab; 10 µg BP | $361.00 |