CDKN2B/p15 INK4B Antibody (DCS114.1): sc-65223

p15 INK4B Antibody (DCS114.1) is a mouse monoclonal IgG1 kappa light chain antibody designed to detect the human p15 INK4B protein, also known as CDKN2B, p15, INK4B, CDK4I, TP15, or MTS2. anti-p15 INK4B antibody (DCS114.1) is raised against a His-tagged recombinant full-length p15 INK4B protein, ensuring strong and reliable binding for various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). The p15 INK4B protein plays a critical role in regulating the cell cycle by inhibiting cyclin-dependent kinases Cdk4 and Cdk6, thereby controlling the progression from the G1 to S phase. This function is essential for maintaining proper cell cycle checkpoints and preventing uncontrolled cell proliferation, which is a hallmark of cancerous growth. p15 INK4B acts as a tumor suppressor and is an important effector in TGFβ-mediated cell cycle arrest, with expression being upregulated approximately 30-fold in TGFβ-treated human keratinocytes. Located on chromosome 9p21.3 adjacent to the p16 INK4A gene, the CDKN2B gene encoding p15 INK4B is frequently found at sites of chromosomal abnormalities in various human tumors, highlighting significance in cancer biology. p15 INK4B (DCS114.1) antibody facilitates the study of regulatory mechanisms and role in tumor suppression, making this reagent an invaluable tool for researchers investigating cell cycle regulation and cancer therapeutics.

The preferred CDKN2B/CDKN2A/p16 antibody is CDKN2B/CDKN2A/p16 Antibody (C-7): sc-377412.