CDKN2B/CDKN2A/p16 Antibody (C-7): sc-377412

p15 INK4B/p16 INK4A Antibody (C-7) is a mouse monoclonal IgG1 kappa light chain antibody, designed to detect both the p15 INK4B and p16 INK4A proteins. anti-p15 INK4B/p16 INK4A antibody (C-7) targets an epitope within amino acids 96-138 at the C-terminus of human p15 INK4B. The p15 INK4B protein, also referred to as CDKN2B, P15, MTS2, TP15, CDK4, and INK4B, and the p16 INK4A protein, also known as CDKN2A, Arf, p16, MTS1, Pctr1, and p19ARF, are crucial regulators of the cell cycle. Both p15 INK4B and p16 INK4A act as inhibitors of cyclin-dependent kinases Cdk4 and Cdk6, which play an essential role in controlling the transition of cells through the G1 phase of the cell cycle. Post-translational modifications of p15 INK4B and p16 INK4A, such as phosphorylation and ubiquitination, play a pivotal role in regulating their stability, localization, and interaction with other cellular proteins, which is crucial for their function in cell cycle arrest and tumor suppression. p15 INK4B/p16 INK4A monoclonal antibody (C-7) recognizes these proteins across mouse, rat, and human species, as well as additional species including bovine and porcine, making this product versatile for various experimental applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Available in both non-conjugated and multiple conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and several Alexa Fluor® variants, p15 INK4B/p16 INK4A (C-7) antibody provides flexibility to accommodate diverse research needs.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-CDKN2B/CDKN2A/p16 Antibody (C-7) has 53 citations in a variety of scientific publications.

Primary antibodies like Anti-CDKN2B/CDKN2A/p16 Antibody (C-7) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

CDKN2B/CDKN2A/p16 Antibody (C-7) Specifications

Alternate Product Name: p15 INK4B/p16 INK4A

Product Clone Name: C-7

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 96-138

Epitope Target: p15 INK4B

Epitope Species: human

Product Reactivity/Detection: p15 INK4B and p16 INK4A

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 53 citations in various scientific publications

Available Conjugates/Forms for CDKN2B/CDKN2A/p16 Antibody (C-7): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin