p-Stat4 Antibody (pY693.38): sc-136194
- p-Stat4 Antibody (pY693.38) is a mouse monoclonal IgG2b κ, cited in 1 publications, provided at 200 µg/ml
- raised against a short amino acid sequence containing phosphorylated Tyr 693 of Stat4 of human origin
- recommended for detection of Tyr 693 phosphorylated Stat4 of mouse, rat and human origin by WBIP
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for p-Stat4 Antibody (pY693.38). This work is in progress.
p-Stat4 Antibody (pY693.38) is a mouse monoclonal IgG2b antibody that detects p-Stat4 in mouse, rat, and human samples through applications such as western blotting (WB) and immunoprecipitation (IP). p-Stat4 monoclonal antibody (pY693.38) plays a crucial role in the signaling pathways activated by various ligands, including interferons and growth hormones, which induce the activation of Janus kinases (Jak). This activation leads to the tyrosine phosphorylation of Stat transcription factors, particularly Stat4, which is essential for mediating interleukin-12 (IL-12) signals. Stat4 is predominantly expressed in testis and myeloid cells, and Stat4 activation is vital for the immune response, as p-Stat4 facilitates the transcription of genes involved in T cell differentiation and function. Upon phosphorylation, Stat4 dimerizes and translocates to the nucleus, where p-Stat4 binds to specific regulatory elements that control gene expression. Notably, the phosphorylation of Ser 721 of Stat4 is dependent on p38 MAPK and is critical for transcriptional activity, highlighting the importance of post-translational modifications in regulating Stat4′s function in immune signaling.
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p-Stat4 Antibody (pY693.38) References:
- Importance of the MKK6/p38 pathway for interleukin-12-induced STAT4 serine phosphorylation and transcriptional activity. | Visconti, R., et al. 2000. Blood. 96: 1844-52. PMID: 10961885
- Role of the Stat4 N domain in receptor proximal tyrosine phosphorylation. | Murphy, TL., et al. 2000. Mol Cell Biol. 20: 7121-31. PMID: 10982828
- Specific down-regulation of interleukin-12 signaling through induction of phospho-STAT4 protein degradation. | Wang, KS., et al. 2001. Blood. 97: 3860-6. PMID: 11389027
- STAT4 serine phosphorylation is critical for IL-12-induced IFN-gamma production but not for cell proliferation. | Morinobu, A., et al. 2002. Proc Natl Acad Sci U S A. 99: 12281-6. PMID: 12213961
- STAT4 requires the N-terminal domain for efficient phosphorylation. | Chang, HC., et al. 2003. J Biol Chem. 278: 32471-7. PMID: 12805384
- Frontline: absence of functional STAT4 activation despite detectable tyrosine phosphorylation induced by murine IFN-alpha. | Berenson, LS., et al. 2004. Eur J Immunol. 34: 2365-74. PMID: 15307169
- Role of H1 receptors in histamine-mediated up-regulation of STAT4 phosphorylation. | Liu, Z., et al. 2006. Int Immunopharmacol. 6: 485-93. PMID: 16428084
- Decreased phosphorylation of STAT-1, STAT-4 and cytokine release in MDR-TB patients with primary resistance. | Kim, HJ., et al. 2008. Int J Tuberc Lung Dis. 12: 1071-6. PMID: 18713507
- Renin Promotes STAT4 Phosphorylation to Induce IL-17 Production in Keratinocytes of Oral Lichen Planus. | Ge, X., et al. 2020. iScience. 23: 100983. PMID: 32213463
- Interleukin 12 induces tyrosine phosphorylation and activation of STAT4 in human lymphocytes. | Bacon, CM., et al. 1995. Proc Natl Acad Sci U S A. 92: 7307-11. PMID: 7638186
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
p-Stat4 Antibody (pY693.38) | sc-136194 | 200 µg/ml | $316.00 |