p-Stat3 Antibody (6D779): sc-71792

p-Stat3 Antibody (6D779) is a mouse monoclonal IgG1 antibody that detects p-Stat3 in mouse, rat, human, and canine samples through applications such as western blotting (WB) and immunoprecipitation (IP). p-Stat3 is a critical component of the signal transducer and activator of transcription (Stat) family, which plays a vital role in mediating cellular responses to various cytokines and growth factors. As a member of the Stat family, p-Stat3 integrates extracellular signals into precise transcriptional responses that influence processes such as inflammation, immune regulation, and tissue repair. p-Stat3 acts downstream of receptors like gp130 and the epidermal growth factor receptor (EGFR), linking ligand binding to specific gene activation. Upon activation, Stat3 undergoes phosphorylation at specific tyrosine residues, which is essential for dimerization and subsequent translocation to the nucleus, where p-Stat3 regulates the expression of genes involved in cell proliferation, survival, and differentiation. p-Stat3 cooperates with other transcription factors to regulate a wide array of target genes, amplifying impact on diverse cellular pathways. This process is particularly important in cancer contexts, as aberrant Stat3 activation is often associated with tumorigenesis and poor prognosis. p-Stat3 (6D779) antibody specifically recognizes the phosphorylated form of Stat3, allowing researchers to investigate activation status in various biological contexts, including studies on immune responses and cancer biology. By utilizing anti-p-Stat3 antibody (6D779), scientists can gain insights into regulatory mechanisms of Stat3 and interactions with other signaling pathways, ultimately contributing to a better understanding of roles in health and disease.

The preferred p-Stat3 antibody is p-Stat3 Antibody (B-7): sc-8059.