p-p38 MAPK Antibody (E-1): sc-166182

p-p38 MAPK Antibody (E-1) is a mouse monoclonal IgG2a kappa light chain antibody that specifically detects Tyr 182 phosphorylated p38 alpha MAPK14, p38 beta MAPK11, and p38 gamma MAPK12 in mouse, rat, and human samples through western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). p-p38 MAPK (E-1) antibody is available in non-conjugated form and conjugated to agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® variants. p38 MAPK proteins are essential mediators of cellular stress responses and inflammatory signals, regulating biological processes including cell differentiation, apoptosis, and cytokine production. p38 MAPK proteins primarily reside in the cytoplasm but can move to the nucleus in response to specific stimuli, enabling direct influence on gene expression and impact on cell cycle regulation and survival. Post-translational modifications, particularly phosphorylation on threonine and tyrosine residues, are crucial for p38 MAPK activation and downstream signaling cascades. anti-p38 MAPK antibody (E-1) serves as a valuable research tool for investigating p38 MAPK signaling pathways and their roles in cancer and inflammatory disorders.

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p-p38 MAPK Antibody (E-1) References:

1. Age-associated changes in the subcellular localization of phosphorylated p38 MAPK in human granulosa cells.  |  Ito, M., et al. 2010. Mol Hum Reprod. 16: 928-37. PMID: 20833869
2. Taurine attenuates liver injury by downregulating phosphorylated p38 MAPK of Kupffer cells in rats with severe acute pancreatitis.  |  Wei, S., et al. 2012. Inflammation. 35: 690-701. PMID: 21833764
3. [Hydrogen sulfide reduces lipopolysaccharide-induced acute lung injury and inhibits expression of phosphorylated p38 MAPK in rats].  |  Fan, YM., et al. 2012. Sheng Li Xue Bao. 64: 666-72. PMID: 23258330
4. Curcumin I mediates neuroprotective effect through attenuation of quinoprotein formation, p-p38 MAPK expression, and caspase-3 activation in 6-hydroxydopamine treated SH-SY5Y cells.  |  Meesarapee, B., et al. 2014. Phytother Res. 28: 611-6. PMID: 23857913
5. Knockdown of COPS3 inhibits the progress of prostate cancer through reducing phosphorylated p38 MAPK expression and impairs the epithelial-mesenchymal transition process.  |  Zhu, Z., et al. 2019. Prostate. 79: 1823-1831. PMID: 31509289
6. Muramyl dipeptide promotes Aβ1-42 oligomer production via the NOD2/p-p38 MAPK/BACE1 signaling pathway in the SH-SY5Y cells.  |  Chen, YJ., et al. 2020. J Integr Neurosci. 19: 421-428. PMID: 33070520
7. Inhibitory effect of isomorellin on cholangiocarcinoma cells via suppression of NF-κB translocation, the phosphorylated p38 MAPK pathway and MMP-2 and uPA expression.  |  Hahnvajanawong, C., et al. 2021. Exp Ther Med. 21: 151. PMID: 33456518
8. MicroRNA-139-5p Regulates Fibrotic Potentials via Modulation of Collagen Type 1 and Phosphorylated p38 MAPK in Uterine Leiomyoma.  |  Ahn, SH., et al. 2021. Yonsei Med J. 62: 726-733. PMID: 34296550
9. SHED-derived exosomes attenuate trigeminal neuralgia after CCI of the infraorbital nerve in mice via the miR-24-3p/IL-1R1/p-p38 MAPK pathway.  |  Guo, R., et al. 2023. J Nanobiotechnology. 21: 458. PMID: 38031158
10. Clemastine mitigates sepsis-induced acute kidney injury in rats; the role of α-Klotho/TLR-4/MYD-88/NF-κB/ Caspase-3/ p-P38 MAPK signaling pathways.  |  Abdelnaser, M., et al. 2025. Arch Biochem Biophys. 763: 110229. PMID: 39608427

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-p-p38 MAPK Antibody (E-1) has 258 citations in a variety of scientific publications.

Primary antibodies like Anti-p-p38 MAPK Antibody (E-1) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

p-p38 MAPK Antibody (E-1) Specifications

Alternate Product Name: p38 MAPK

Product Clone Name: E-1

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: Tyr 182

Epitope Target: p38 alpha MAPK14

Epitope Species: human

Product Reactivity/Detection: Tyr 182 phosphorylated p38 alpha MAPK14, p38 beta MAPK11 and p38 gamma MAPK12

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: equine, canine, bovine, porcine and avian

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 258 citations in various scientific publications

Available Conjugates/Forms for p-p38 MAPK Antibody (E-1): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin

The preferred p-p38 MAPK antibody is p-p38 MAPK Antibody (D-8): sc-7973.