p-p120 Antibody (pY280.18): sc-136016

p-p120 Antibody (pY280.18) is a mouse monoclonal IgG1 antibody that detects p120 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). p120, also known as cadherin-associated Src substrate, is a crucial protein that plays a significant role in cellular adhesion by interacting with E-cadherin and other catenins. p120 is primarily located in the cytoplasm, nucleus, and cell membrane of vascular endothelial cells, which is vital for mediating cell signaling and maintaining tissue integrity. p120 participates in ligand-induced receptor signaling pathways involving epidermal growth factor, platelet-derived growth factor, colony-stimulating factor-1, and Neu receptors, thereby influencing various cellular processes such as proliferation and differentiation. p120 undergoes post-translational modifications, including phosphorylation, which can modulate activity and interactions with other proteins. With four major isoforms resulting from alternative splicing, p120 exhibits a complex regulatory mechanism essential for diverse functions in cellular signaling and adhesion. anti-p120 antibody (pY280.18) is an invaluable tool for researchers studying p120′s intricate roles in cellular dynamics and implications in various biological processes.

The preferred p120 antibody is p120 Antibody (15D2): sc-23872.