p-NF-H Antibody (NF-01): sc-51682
- p-NF-H Antibody (NF-01) is a mouse monoclonal IgG1, cited in 2 publications, provided at 100 µg/ml
- raised against porcine brain
- recommended for detection of a phosphorylated epitope on heavy neurofilment of mouse, rat, human and porcine origin by WB, IP, IF and IHC(P)
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for p-NF-H Antibody (NF-01). This work is in progress.
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p-NF-H Antibody (NF-01) is a mouse monoclonal IgG1 antibody that detects neurofilament-H (NF-H) in mouse, rat, human, and porcine samples through western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. Anti-NF-H antibody (NF-01) specifically recognizes phosphorylated forms of NF-H, a crucial component of the neuronal cytoskeleton that maintains structural integrity of neurons. Phosphorylation of NF-H regulates the assembly and stability of neurofilaments, essential for proper axonal transport and neuronal function. Dysregulation of NF-H phosphorylation has been implicated in various neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS), Parkinson′s disease, and Alzheimer′s disease, making NF-H (NF-01) monoclonal antibody a valuable tool for researchers studying these conditions. Anti-NF-H antibody (NF-01) enables scientists to gain insights into pathological mechanisms underlying neurodegeneration and explore potential therapeutic targets.
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LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
p-NF-H Antibody (NF-01) References:
- Effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine on differentiating mouse N2a neuroblastoma cells. | De Girolamo, LA., et al. 2000. J Neurochem. 75: 133-40. PMID: 10854256
- Neurofilament proteins and cAMP pathway in brains of mu-, delta- or kappa-opioid receptor gene knock-out mice: effects of chronic morphine administration. | García-Sevilla, JA., et al. 2004. Neuropharmacology. 46: 519-30. PMID: 14975676
- Quantitative evidence for neurofilament heavy subunit aggregation in motor neurons of spinal cords of patients with amyotrophic lateral sclerosis. | Mendonça, DM., et al. 2005. Braz J Med Biol Res. 38: 925-33. PMID: 15933787
- Soluble, phosphorylated forms of the high molecular weight neurofilament protein in perikarya of cultured neuronal cells. | Shea, TB., et al. 1988. Neurosci Lett. 92: 291-7. PMID: 2462197
- Serum Levels of Neurofilament-H are Elevated in Patients Suffering From Severe Burns. | Gatson, JW., et al. 2015. J Burn Care Res. 36: 545-50. PMID: 25377862
- SNTF immunostaining reveals previously undetected axonal pathology in traumatic brain injury. | Johnson, VE., et al. 2016. Acta Neuropathol. 131: 115-35. PMID: 26589592
- Axon hyperexcitability in the contralateral projection following unilateral optic nerve crush in mice. | McGrady, NR., et al. 2022. Brain Commun. 4: fcac251. PMID: 36267329
- Deposition of detergent-resistant neurofilaments into Lewy body fibrils. | Pollanen, MS., et al. 1993. Brain Res. 603: 121-4. PMID: 7680936
- Respective roles of neurofilaments, microtubules, MAP1B, and tau in neurite outgrowth and stabilization. | Shea, TB. and Beermann, ML. 1994. Mol Biol Cell. 5: 863-75. PMID: 7803854
- Interaction of the tail domain of high molecular weight subunits of neurofilaments with the COOH-terminal region of tubulin and its regulation by tau protein kinase II. | Miyasaka, H., et al. 1993. J Biol Chem. 268: 22695-702. PMID: 8226779
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
p-NF-H Antibody (NF-01) | sc-51682 | 100 µg/ml | $316.00 |