p-NF-H Antibody (NAP4): sc-53798
- p-NF-H Antibody (NAP4) is a mouse monoclonal IgG1 provided at 50 µl ascites
- raised against native p-NF-H of porcine origin
- recommended for detection of p-NF-H of mouse, rat, human and porcine origin by WB, IP, IF and IHC(P)
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for p-NF-H Antibody (NAP4). This work is in progress.
p-NF-H Antibody (NAP4) is a mouse monoclonal IgG1 antibody that detects p-NF-H in mouse, rat, human, and porcine samples through western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. p-NF-H (NAP4) antibody is available in a non-conjugated form, providing flexibility for various experimental needs. Neurofilament-H, or NF-H, is a crucial component of the neuronal cytoskeleton, playing a significant role in maintaining neuronal structural integrity. NF-H is primarily located in neuronal axons, where NF-H contributes to axon caliber regulation and overall neuronal architecture stability. Proper NF-H functioning is vital for neuronal health, as alterations in expression or phosphorylation status can lead to neurodegenerative conditions such as amyotrophic lateral sclerosis (ALS), Parkinson′s disease, and Alzheimer′s disease. The dynamic nature of neurofilaments, including interaction with other cytoskeletal elements like microtubules and actin filaments, underscores NF-H importance in neuronal function and pathology. Using anti-p-NF-H antibody (NAP4) in research can provide valuable insights into neurofilament roles in health and disease.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
p-NF-H Antibody (NAP4) References:
- Quantitative analysis of neurofilament proteins in Alzheimer brain by enzyme linked immunosorbent assay system. | Hashimoto, R., et al. 1999. Psychiatry Clin Neurosci. 53: 587-91. PMID: 10595684
- Brain-derived neurotrophic factor-induced phosphorylation of neurofilament-H subunit in primary cultures of embryo rat cortical neurons. | Tokuoka, H., et al. 2000. J Cell Sci. 113 (Pt 6): 1059-68. PMID: 10683153
- Regulation of nonphosphorylated and phosphorylated forms of neurofilament proteins in the prefrontal cortex of human opioid addicts. | Ferrer-Alcón, M., et al. 2000. J Neurosci Res. 61: 338-49. PMID: 10900081
- Axon- or dendrite-predominant outgrowth induced by constituents from Ashwagandha. | Kuboyama, T., et al. 2002. Neuroreport. 13: 1715-20. PMID: 12395110
- Downregulation of neuronal cdk5/p35 in opioid addicts and opiate-treated rats: relation to neurofilament phosphorylation. | Ferrer-Alcón, M., et al. 2003. Neuropsychopharmacology. 28: 947-55. PMID: 12637947
- Spontaneous perikaryal neurofilament phosphorylation in the septofimbrial nucleus of the rat. | Klosen, P. and van den Bosch de Aguilar, P. 1992. Neurosci Lett. 139: 108-13. PMID: 1407676
- Dynamics of mammalian high-molecular-weight neurofilament subunit phosphorylation in cultured rat sympathetic neurons. | Clark, EA. and Lee, VM. 1991. J Neurosci Res. 30: 116-23. PMID: 1795396
- Dynamics of phosphorylation and assembly of the high molecular weight neurofilament subunit in NB2a/d1 neuroblastoma. | Shea, TB., et al. 1990. J Neurochem. 55: 1784-92. PMID: 2213024
- Abolishing UCHL1's hydrolase activity exacerbates TBI-induced axonal injury and neuronal death in mice. | Mi, Z., et al. 2021. Exp Neurol. 336: 113524. PMID: 33159930
- Cerebrospinal fluid biomarkers of white matter injury and astrogliosis are associated with the severity and surgical outcome of degenerative cervical spondylotic myelopathy. | Tsitsopoulos, PP., et al. 2022. Spine J. 22: 1848-1856. PMID: 35753639
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
p-NF-H Antibody (NAP4) | sc-53798 | 50 µl ascites | $322.00 |