p-NF-H Antibody (7H11): sc-20015
- p-NF-H Antibody (7H11) is a mouse monoclonal IgM, cited in 1 publications, provided at 200 µg/ml
- raised against recombinant full length protein
- recommended for detection of phosphorylatedNF-H of mouse, rat and human origin by WB, IP, IF and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for p-NF-H Antibody (7H11). This work is in progress.
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p-NF-H Antibody (7H11) is a mouse monoclonal IgM antibody that detects neurofilament-H in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-neurofilament-H antibody (7H11) specifically targets neurofilament-H, a crucial component of the neuronal cytoskeleton that plays a significant role in maintaining the structural integrity of neurons. Neurofilament-H is essential for regulating axon caliber, which is vital for proper nerve signal conduction and overall neuronal function. Neurofilament-H′s dynamic nature is underscored by numerous phosphorylation sites, which are targeted by various kinases, including protein kinase A and cyclin-dependent kinase 5. These post-translational modifications are critical as they can influence neurofilament assembly and stability, and alterations in their regulation are often linked to neurodegenerative diseases such as amyotrophic lateral sclerosis, Parkinson′s disease, and Alzheimer′s disease. Anti-neurofilament-H antibody (7H11) enables researchers to gain insights into neurofilament-H′s role in both healthy and diseased states, making this antibody an invaluable tool for studying neuronal health and pathology.
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p-NF-H Antibody (7H11) References:
- Hyperphosphorylated neurofilament NF-H is a serum biomarker of axonal injury. | Shaw, G., et al. 2005. Biochem Biophys Res Commun. 336: 1268-77. PMID: 16176808
- Inhibition of Pin1 reduces glutamate-induced perikaryal accumulation of phosphorylated neurofilament-H in neurons. | Kesavapany, S., et al. 2007. Mol Biol Cell. 18: 3645-55. PMID: 17626162
- Detection of phosphorylated NF-H in the cerebrospinal fluid and blood of aneurysmal subarachnoid hemorrhage patients. | Lewis, SB., et al. 2008. J Cereb Blood Flow Metab. 28: 1261-71. PMID: 18319731
- Folate is related to phosphorylated neurofilament-H and P-tau (Ser396) in rat brain. | Obeid, R., et al. 2011. J Neurochem. 117: 1047-54. PMID: 21517845
- Transfected rat high-molecular-weight neurofilament (NF-H) coassembles with vimentin in a predominantly nonphosphorylated form. | Chin, SS. and Liem, RK. 1990. J Neurosci. 10: 3714-26. PMID: 2230956
- Neurofilament Proteins as Prognostic Biomarkers in Neurological Disorders. | Lee, Y., et al. 2020. Curr Pharm Des. 25: 4560-4569. PMID: 31820696
- Serum Phosphorylated Neurofilament Heavy Subunit Levels and its Association with the Risk for Catastrophic Injury in Thoroughbred Racehorses. | Rojas-Núñez, I., et al. 2022. J Equine Vet Sci. 116: 104057. PMID: 35772595
- Expression of phosphorylated high molecular weight neurofilament protein (NF-H) and vimentin in human developing dorsal root ganglia and spinal cord. | Lukás, Z., et al. 1993. Histochemistry. 100: 495-502. PMID: 8163392
- Changes in neurofilament protein NF-L and NF-H immunoreactivity following kainic acid-induced seizures. | Wang, S., et al. 1994. J Neurochem. 62: 739-48. PMID: 8294936
- Isolation and characterization of the highly phosphorylated repeat domain of distinct heavy neurofilament subunit (NF-H) isoforms. | Soussan, L., et al. 1996. Cell Mol Neurobiol. 16: 463-77. PMID: 8879749
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
p-NF-H Antibody (7H11) | sc-20015 | 200 µg/ml | $322.00 |