p-MDM2 Antibody (2G2): sc-53368
- p-MDM2 Antibody (2G2) is a mouse monoclonal IgG1, cited in 4 publications, provided at 200 µg/ml
- raised against synthetic peptide corresponding to amino acids Ser 186 containing phosphorylated Ser 186 of MDM2 of human origin
- recommended for detection of Ser 186 phosphorylated MDM2 of mouse, rat and human origin by WB
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for p-MDM2 Antibody (2G2). This work is in progress.
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p-MDM2 Antibody (2G2) is a mouse monoclonal IgG1 antibody that detects p-MDM2 in mouse, rat, and human samples through western blotting (WB). p-MDM2 plays a critical role in regulating the p53 tumor suppressor pathway, which is essential for maintaining genomic stability and preventing tumorigenesis. p-MDM2 interacts with p53, leading to its ubiquitination and subsequent degradation, thereby modulating cellular response to stress and DNA damage. This interaction is particularly important because p53 is a key player in cell cycle regulation and apoptosis, and its dysfunction is commonly associated with various cancers. MDM2 phosphorylation at specific residues, such as Thr 218, can enhance p53 binding, further influencing the balance between cell survival and death in response to DNA-damaging agents. Anti-p-MDM2 antibody (2G2) helps researchers gain insights into p53 regulation mechanisms and MDM2 overexpression implications in cancer biology, making p-MDM2 (2G2) monoclonal antibody a valuable tool for studies focused on tumorigenesis and therapeutic interventions.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
p-MDM2 Antibody (2G2) | sc-53368 | 200 µg/ml | $322.00 |