p-MDM2 Antibody (2G2): sc-53368
- p-MDM2 Antibody (2G2) is a mouse monoclonal IgG1, cited in 4 publications, provided at 200 µg/ml
- raised against synthetic peptide corresponding to amino acids Ser 186 containing phosphorylated Ser 186 of MDM2 of human origin
- recommended for detection of Ser 186 phosphorylated MDM2 of mouse, rat and human origin by WB
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for p-MDM2 Antibody (2G2). This work is in progress.
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p-MDM2 Antibody (2G2) is a mouse monoclonal IgG1 antibody that detects p-MDM2 in mouse, rat, and human samples through western blotting (WB). p-MDM2 plays a critical role in regulating the p53 tumor suppressor pathway, which is essential for maintaining genomic stability and preventing tumorigenesis. p-MDM2 interacts with p53, leading to its ubiquitination and subsequent degradation, thereby modulating cellular response to stress and DNA damage. This interaction is particularly important because p53 is a key player in cell cycle regulation and apoptosis, and its dysfunction is commonly associated with various cancers. MDM2 phosphorylation at specific residues, such as Thr 218, can enhance p53 binding, further influencing the balance between cell survival and death in response to DNA-damaging agents. Anti-p-MDM2 antibody (2G2) helps researchers gain insights into p53 regulation mechanisms and MDM2 overexpression implications in cancer biology, making p-MDM2 (2G2) monoclonal antibody a valuable tool for studies focused on tumorigenesis and therapeutic interventions.
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p-MDM2 Antibody (2G2) References:
- MDM2: life without p53. | Daujat, S., et al. 2001. Trends Genet. 17: 459-64. PMID: 11485818
- Mdm2-mediated ubiquitylation: p53 and beyond. | Marine, JC. and Lozano, G. 2010. Cell Death Differ. 17: 93-102. PMID: 19498444
- Resistance acquisition to MDM2 inhibitors. | Cinatl, J., et al. 2014. Biochem Soc Trans. 42: 752-7. PMID: 25109953
- Splice variants of MDM2 in oncogenesis. | Rosso, M., et al. 2014. Subcell Biochem. 85: 247-61. PMID: 25201199
- Modulation of the p53/MDM2 interplay by HAUSP inhibitors. | Tavana, O. and Gu, W. 2017. J Mol Cell Biol. 9: 45-52. PMID: 27927749
- Role of Mdm2 and Mdmx in DNA repair. | Eischen, CM. 2017. J Mol Cell Biol. 9: 69-73. PMID: 27932484
- Mdm2 phosphorylation by Akt regulates the p53 response to oxidative stress to promote cell proliferation and tumorigenesis. | Chibaya, L., et al. 2021. Proc Natl Acad Sci U S A. 118: PMID: 33468664
- Adipose MDM2 regulates systemic insulin sensitivity. | Hallenborg, P., et al. 2021. Sci Rep. 11: 21839. PMID: 34750429
- p90RSK Regulates p53 Pathway by MDM2 Phosphorylation in Thyroid Tumors. | Maietta, I., et al. 2022. Cancers (Basel). 15: PMID: 36612117
- MDM2 for the practicing pathologist: a primer. | Menon, AA., et al. 2023. J Clin Pathol. 76: 285-290. PMID: 36898827
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
p-MDM2 Antibody (2G2) | sc-53368 | 200 µg/ml | $322.00 |