p-Integrin α4/ITGA4/CD49d Antibody (αPSα4): sc-23943

p-Integrin α4 Antibody (αPSα4) is a mouse monoclonal IgG antibody that detects p-Integrin α4 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). p-Integrin α4 plays a crucial role in cell adhesion and signaling, functioning as a key component of the integrin family, which consists of heterodimers formed by noncovalently associated transmembrane α and β subunits. p-Integrin α4 specifically interacts with various ligands, including fibronectin and vascular cell adhesion molecule-1 (VCAM-1), facilitating important cellular processes such as leukocyte migration and tissue infiltration during immune responses. p-Integrin α4 mediates interactions vital for maintaining proper immune function and tissue homeostasis, influencing cell adhesion, migration, and overall inflammatory response. anti-p-Integrin α4 antibody (αPSα4) enables researchers to gain insights into integrin-mediated signaling mechanisms and implications in various physiological and pathological conditions, including autoimmune diseases and cancer.

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p-Integrin α4/ITGA4/CD49d Antibody (αPSα4) References:

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2. Functional and structural analysis of VLA-4 integrin alpha 4 subunit cleavage.  |  Teixidó, J., et al. 1992. J Biol Chem. 267: 1786-91. PMID: 1730718
3. NG2, a novel proapoptotic receptor, opposes integrin alpha4 to mediate anoikis through PKCalpha-dependent suppression of FAK phosphorylation.  |  Joo, NE., et al. 2008. Cell Death Differ. 15: 899-907. PMID: 18292781
4. An integrin-alpha4-14-3-3zeta-paxillin ternary complex mediates localised Cdc42 activity and accelerates cell migration.  |  Deakin, NO., et al. 2009. J Cell Sci. 122: 1654-64. PMID: 19401330
5. Aberrant DNA methylation of integrin alpha4: a potential novel role for metastasis of cholangiocarcinoma.  |  Uhm, KO., et al. 2010. J Cancer Res Clin Oncol. 136: 187-94. PMID: 19655168
6. Characterization of the alpha 4 integrin gene promoter.  |  Rosen, GD., et al. 1991. Proc Natl Acad Sci U S A. 88: 4094-8. PMID: 2034655
7. The primary structure of the alpha 4 subunit of VLA-4: homology to other integrins and a possible cell-cell adhesion function.  |  Takada, Y., et al. 1989. EMBO J. 8: 1361-8. PMID: 2788572
8. Integrin α4 mediates ATDC5 cell adhesion to negatively charged synthetic polymer hydrogel leading to chondrogenic differentiation.  |  Hashimoto, D., et al. 2020. Biochem Biophys Res Commun. 528: 120-126. PMID: 32456794
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11. Epithelial integrins.  |  Sheppard, D. 1996. Bioessays. 18: 655-60. PMID: 8760339
12. Cooperation between soluble factors and integrin-mediated cell anchorage in the control of cell growth and differentiation.  |  Juliano, R. 1996. Bioessays. 18: 911-7. PMID: 8939069

The preferred Integrin α4/ITGA4/CD49d antibody is Integrin α4/ITGA4/CD49d Antibody (A-7): sc-365209.