p-IGF-1 Receptor/IGF1R Antibody (50.Y1165/1166): sc-135767

p-IGF-IR Antibody (50.Y1165/1166) is a mouse monoclonal IgG1 antibody that detects insulin-like growth factor-I receptor (IGF-IR) in human samples through applications such as western blotting (WB) and enzyme-linked immunosorbent assay (ELISA). Anti-IGF-IR antibody (50.Y1165/1166) plays a crucial role in studying IGF-IR function, a receptor tyrosine kinase integral to various cellular processes, including growth, survival, and differentiation. IGF-IR is primarily located on the cell membrane, where IGF-IR acts as a transmembrane molecular scaffold facilitating insulin-like growth factor-I (IGF-I) binding. This interaction triggers downstream signaling pathways that influence cell proliferation and metabolism, making IGF-IR essential in both normal physiological processes and pathological conditions, such as cancer. IGF-IR′s ability to block apoptosis and promote cell growth underscores IGF-IR′s importance in tumorigenesis, as aberrant IGF-IR signaling can lead to uncontrolled cell division and survival. Understanding IGF-IR dynamics and interactions with other signaling molecules is essential for developing targeted therapies in cancer treatment and other diseases associated with dysregulated growth factor signaling.

The preferred INSR/Insulin Receptor β antibody is INSR/Insulin Receptor β Antibody (CT-3): sc-57342.