p-GSK3 beta Antibody (3A8): sc-81495
- p-GSK3 beta Antibody (3A8) is a mouse monoclonal IgG1, cited in 15 publications, provided at 50 µg/0.5 ml
- raised against phosphopeptide corresponding to amino acid residues surrounding serine 9 of GSK-3β of human origin
- recommended for detection of Ser 9 phosphorylated GSK-3β of mouse, rat, human and canine origin by WB and IP
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for p-GSK3 beta Antibody (3A8). This work is in progress.
p-GSK-3β Antibody (3A8) is a mouse monoclonal IgG1 antibody that detects glycogen synthase kinase-3β (GSK-3β) in mouse, rat, human, and canine samples through western blotting (WB) and immunoprecipitation (IP) applications. anti-GSK-3β antibody (3A8) specifically recognizes the phosphorylated form of GSK-3β, which plays a crucial role in various cellular processes, including energy metabolism, cell proliferation, and apoptosis regulation. GSK-3β is primarily located in the cytoplasm but can translocate to the nucleus, where GSK-3β influences the activity of transcription factors and other proteins involved in cell signaling pathways. This subcellular localization is vital because GSK-3β modulates the activity of key proteins that govern cellular responses to growth factors and stress signals. For instance, GSK-3β′s nuclear activity is essential for the anti-apoptotic response mediated by Rel dimers in response to tumor necrosis factor-alpha (TNFα), highlighting GSK-3β′s importance in cell survival and differentiation. The phosphorylation state of GSK-3β, regulated by various kinases, determines GSK-3β′s activity and interaction with other proteins, making GSK-3β a critical player in maintaining cellular homeostasis. GSK-3β monoclonal antibody (3A8) enables researchers to gain insights into the regulatory mechanisms of GSK-3β and its implications in diseases such as cancer and neurodegenerative disorders.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
p-GSK3 beta Antibody (3A8) | sc-81495 | 50 µg/0.5 ml | $322.00 |