p-GSK3 beta Antibody (2D3): sc-81494
- p-GSK3 beta Antibody (2D3) is a mouse monoclonal IgG1, cited in 11 publications, provided at 50 µg/0.5 ml
- raised against phosphopeptide corresponding to amino acid residues surrounding serine 9 of GSK-3β of human origin
- recommended for detection of Ser 9 phosphorylated GSK-3β of mouse, rat and human origin by WB and IP
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for p-GSK3 beta Antibody (2D3). This work is in progress.
p-GSK-3β Antibody (2D3) is a mouse monoclonal IgG1 antibody that detects glycogen synthase kinase-3β (GSK-3β) in mouse, rat, and human samples through western blotting (WB) and immunoprecipitation (IP) applications. Anti-p-GSK-3β antibody (2D3) specifically recognizes the phosphorylated form of GSK-3β, which plays a crucial role in various cellular processes, including energy metabolism, cell proliferation, and apoptosis regulation. GSK-3β is primarily located in the cytoplasm but can translocate to the nucleus, where GSK-3β influences the activity of transcription factors and other signaling pathways. This subcellular localization is vital because GSK-3β modulates gene expression in response to extracellular signals, thereby impacting cellular responses to growth factors and stress. The phosphorylation state of GSK-3β, particularly at Ser 9, is a key regulatory mechanism that determines activity; when phosphorylated, GSK-3β is inactivated, which is essential for promoting cell survival and growth. GSK-3β interacts with various proteins, including cAMP-dependent protein kinase A, which also phosphorylates GSK-3β, highlighting the intricate regulatory networks that control function. p-GSK-3β (2D3) antibody specifically detects phosphorylated GSK-3β, making p-GSK-3β (2D3) antibody an invaluable tool for researchers studying the signaling pathways involved in cell growth and survival.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
p-GSK3 beta Antibody (2D3) | sc-81494 | 50 µg/0.5 ml | $316.00 |