p-CD130/gp130 Antibody (D-3): sc-377570

p-gp130 Antibody (D-3) is a mouse monoclonal IgG2b antibody that detects gp130 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). anti-gp130 antibody (D-3) specifically targets the phosphorylated form of gp130, a critical component of the interleukin-6 (IL-6) signaling pathway, which plays a vital role in immune response, inflammation, and hematopoiesis. gp130 monoclonal antibody (D-3) recognizes a protein primarily located on the cell surface, where gp130 acts as a signal transducer for various cytokines, including IL-6, leukemia inhibitory factor, and oncostatin M. This strategic positioning allows for rapid signal transduction upon ligand binding, facilitating timely cellular responses to external stimuli. Importantly, the phosphorylation of gp130 at specific sites, such as Ser 782, is crucial for regulating internalization and subsequent signaling activity, thereby influencing the overall cellular response to cytokines. gp130 (D-3) antibody′s ability to detect this phosphorylated form makes p-gp130 an invaluable tool for researchers studying the dynamics of IL-6 signaling and its implications in various diseases, including autoimmune disorders and cancers.

The preferred CD130/gp130 antibody is CD130/gp130 Antibody (E-8): sc-376280.