p-EGFR Antibody (9H2): sc-57545

p-EGFR Antibody (9H2) is a mouse monoclonal IgG1 antibody that detects Tyr 1173 phosphorylated EGFR in mouse, rat, human, and canine samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). p-EGFR monoclonal antibody (9H2) is available in a non-conjugated form, allowing for versatile experimental setups. The epidermal growth factor receptor (EGFR) plays a crucial role in cell signaling, mediating cellular responses to growth factors that are vital for processes such as cell proliferation, differentiation, and survival. Located primarily on the cell surface, EGFR is activated upon binding with ligands like EGF or TGFα, which triggers a cascade of intracellular signaling pathways essential for normal cellular function and development. The phosphorylation of specific tyrosine residues, particularly Tyr 1173, is critical for EGFR activation and subsequent signaling, as phosphorylation facilitates recruitment of downstream signaling proteins, including the phosphotyrosine binding domain of GRB2. This interaction is pivotal for activation of the Ras signaling pathway, which is integral to cell growth and division. Dysregulation of EGFR signaling is often implicated in various cancers, making p-EGFR (9H2) antibody a valuable tool for research into cancer biology and therapeutic interventions.

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-p-EGFR Antibody (9H2) has 12 citations in a variety of scientific publications.

Primary antibodies like Anti-p-EGFR Antibody (9H2) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

p-EGFR Antibody (9H2) Specifications

Alternate Product Name: EGFR

Product Clone Name: 9H2

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁

Amino Acids: Tyr 1173

Epitope Target: p-EGFR

Epitope Species: human

Product Reactivity/Detection: Tyr 1173 phosphorylated EGFR

Species Reactivity/Detection: mouse, rat, human, canine

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF

Vialing Information: Each vial contains 50 µg IgG₁ in 0.5 ml of PBS with < 0.1% sodium azide, 0.1% gelatin, PEG and sucrose

Research Citations: 12 citations in various scientific publications

Available Conjugates/Forms for p-EGFR Antibody (9H2): N/A

The preferred EGFR antibody is EGFR Antibody (528): sc-120.