p-CD88 Antibody (32-G1): sc-53793
- p-CD88 Antibody (32-G1) is a mouse monoclonal IgG1 κ, cited in 1 publications, provided at 200 µg/ml
- raised against synthetic CD88 corresponding to 18 C terminal amino acids phosphorylated at Serine 332, 334 and 338 of CD88 of human origin
- recommended for detection of Ser 334 phosphorylated CD88 of human origin by WB, IP and IF
- m-IgG Fc BP-HRP is the preferred secondary detection reagent for p-CD88 Antibody (32-G1) for WB applications. This reagent is now offered in a bundle with p-CD88 Antibody (32-G1) (see ordering information below).
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p-CD88 Antibody (32-G1) is a mouse monoclonal IgG1 antibody that detects p-CD88 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). p-CD88, also known as the phosphorylated form of the C5a receptor (C5aR), is a G protein-coupled integral membrane protein that plays a crucial role in the immune response by mediating the effects of the inflammatory peptide C5a. p-CD88 is predominantly expressed on immune cells such as neutrophils, monocytes, and macrophages, as well as on hepatocytes and various epithelial and endothelial cells, highlighting its importance in both innate immunity and inflammation. The phosphorylation of p-CD88 at serines 332, 334, and 338 is particularly significant, as this modification serves as a key regulatory mechanism that modulates receptor activity. Upon binding with C5a, p-CD88 undergoes rapid phosphorylation, which not only enhances signaling capabilities but also leads to receptor desensitization and internalization, thereby fine-tuning the inflammatory response. p-CD88′s influence on acute phase protein production in the liver and association with inflammation in the brain underscores a critical role in both systemic and localized immune responses, making anti-p-CD88 antibody (32-G1) an essential tool for researchers studying immune signaling pathways and inflammatory processes.
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p-CD88 Antibody (32-G1) References:
- The chemotactic receptor for human C5a anaphylatoxin. | Gerard, NP. and Gerard, C. 1991. Nature. 349: 614-7. PMID: 1847994
- Anaphylatoxins: C3a and C5a. | Hugli, TE. and Müller-Eberhard, HJ. 1978. Adv Immunol. 26: 1-53. PMID: 358800
- Differential expression of complement receptors on human basophils and mast cells. Evidence for mast cell heterogeneity and CD88/C5aR expression on skin mast cells. | Füreder, W., et al. 1995. J Immunol. 155: 3152-60. PMID: 7673728
- Cellular expression of the C5a anaphylatoxin receptor (C5aR): demonstration of C5aR on nonmyeloid cells of the liver and lung. | Haviland, DL., et al. 1995. J Immunol. 154: 1861-9. PMID: 7836770
- Detection of C5a receptors on human eosinophils and inhibition of eosinophil effector functions by anti-C5a receptor (CD88) antibodies. | Elsner, J., et al. 1996. Eur J Immunol. 26: 1560-4. PMID: 8766561
- Expression of the receptor for complement C5a (CD88) is up-regulated on reactive astrocytes, microglia, and endothelial cells in the inflamed human central nervous system. | Gasque, P., et al. 1997. Am J Pathol. 150: 31-41. PMID: 9006319
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
p-CD88 Antibody (32-G1) | sc-53793 | 200 µg/ml | $322.00 | |||
p-CD88 Antibody (32-G1): m-IgG Fc BP-HRP Bundle | sc-539004 | 200 µg Ab; 10 µg BP | $361.00 |