P-cadherin Antibody (A-10): sc-74545

P-cadherin Antibody (A-10) is a mouse monoclonal IgG1 kappa light chain antibody that detects P-cadherin of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). P-cadherin Antibody (A-10) comes in non-conjugated form and various conjugates, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® options. P-cadherin, also known as Cadherin 3 or CDH3, plays a crucial role in cell adhesion, maintaining tissue integrity and facilitating morphogenetic processes during development. P-cadherin localizes primarily in epithelial cell plasma membranes, forming adherens junctions that connect neighboring cells and contribute to tissue structural stability. This specific location enables P-cadherin to interact with cytoskeleton and signaling molecules, influencing cellular behavior and tissue organization. P-cadherin′s interaction with β-catenin and other cytoplasmic proteins regulates cadherin-mediated adhesion, impacting cell migration and differentiation. P-cadherin′s role in mediating these interactions highlights its significance in normal physiological processes and various diseases, including cancer, where altered cadherin expression can increase invasiveness and metastasis.

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Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-P-cadherin Antibody (A-10) has 2 citations in a variety of scientific publications.

Primary antibodies like Anti-P-cadherin Antibody (A-10) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

P-cadherin Antibody (A-10) Specifications

Alternate Product Name: CDH3

Product Clone Name: A-10

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 550-654

Epitope Target: P-cadherin

Epitope Species: human

Product Reactivity/Detection: P-cadherin

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 2 citations in various scientific publications

Available Conjugates/Forms for P-cadherin Antibody (A-10): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin