Oxytocin-R Antibody (C-4): sc-515809

Oxytocin-R Antibody (C-4) is a mouse monoclonal IgG1 kappa light chain antibody that detects Oxytocin-R of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-Oxytocin-R antibody (C-4) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Oxytocin-R, also known as oxytocin receptor, is a critical integral membrane protein belonging to the G protein-coupled receptor family, which plays a vital role in mediating physiological effects of oxytocin, a hormone involved in childbirth and lactation. Oxytocin-R is predominantly located in the uterus and cervix, where expression significantly increases during pregnancy in response to both endocrine and mechanical signals. This localization facilitates uterine contractions necessary for parturition and milk ejection reflex during nursing. Additionally, regulation of Oxytocin-R expression is essential for maintaining reproductive health, as inhibition by factors such as interferon-alpha and interferon-tau may contribute to suppression of oxytocin signaling during early pregnancy, highlighting Oxytocin-R′s importance in reproductive processes.

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Oxytocin-R Antibody (C-4) References:

1. Structure and expression of a human oxytocin receptor.  |  Kimura, T., et al. 1992. Nature. 356: 526-9. PMID: 1313946
2. The Oxytocin Receptor: From Intracellular Signaling to Behavior.  |  Jurek, B. and Neumann, ID. 2018. Physiol Rev. 98: 1805-1908. PMID: 29897293
3. Oxytocin Receptor Signaling in Vascular Function and Stroke.  |  McKay, EC. and Counts, SE. 2020. Front Neurosci. 14: 574499. PMID: 33071746
4. Review of eating disorders and oxytocin receptor polymorphisms.  |  Burmester, V., et al. 2021. J Eat Disord. 9: 85. PMID: 34256847
5. Roles of the Oxytocin Receptor (OXTR) in Human Diseases.  |  Pierzynowska, K., et al. 2023. Int J Mol Sci. 24: PMID: 36835321
6. The oxytocin receptor, luteolysis and the maintenance of pregnancy.  |  Wathes, DC. and Lamming, GE. 1995. J Reprod Fertil Suppl. 49: 53-67. PMID: 7623343
7. Structure, characterization, and expression of the rat oxytocin receptor gene.  |  Rozen, F., et al. 1995. Proc Natl Acad Sci U S A. 92: 200-4. PMID: 7816817
8. Expression of oxytocin receptor in human pregnant myometrium.  |  Kimura, T., et al. 1996. Endocrinology. 137: 780-5. PMID: 8593830
9. Interferon-alpha downregulates expression of the oxytocin receptor in cultured human myometrial cells.  |  Maggi, M., et al. 1996. Am J Physiol. 271: E840-6. PMID: 8944670
10. Central oxytocin and reproductive behaviours.  |  Insel, TR., et al. 1997. Rev Reprod. 2: 28-37. PMID: 9414463
11. Increased expression of the rat myometrial oxytocin receptor messenger ribonucleic acid during labor requires both mechanical and hormonal signals.  |  Ou, CW., et al. 1998. Biol Reprod. 59: 1055-61. PMID: 9780309
12. Up-regulation of oxytocin receptor messenger ribonucleic acid and protein by estradiol in the cervix of ovariectomized rat.  |  Umscheid, CA., et al. 1998. Biol Reprod. 59: 1131-8. PMID: 9780319

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Oxytocin-R Antibody (C-4) has 8 citations in a variety of scientific publications.

Primary antibodies like Anti-Oxytocin-R Antibody (C-4) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Oxytocin-R Antibody (C-4) Specifications

Alternate Product Name: Oxytocin receptor

Product Clone Name: C-4

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 330-389

Epitope Target: Oxytocin-R

Epitope Species: human

Product Reactivity/Detection: Oxytocin-R

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 8 citations in various scientific publications

Available Conjugates/Forms for Oxytocin-R Antibody (C-4): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin