OX2R Antibody (OX102): sc-53101
- OX2R Antibody (OX102) is a mouse monoclonal IgG1 κ OX2R antibody provided at 200 µg/ml
- raised against membrane fraction of thioglycollate-elicited peripheral cells of rat origin
- OX2R Antibody (OX102) is recommended for detection of OX2R of mouse and rat origin by IF and FCM
- Anti-OX2R Antibody (OX102) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for OX2R Antibody (OX102). These reagents are now offered in bundles with OX2R Antibody (OX102) (see ordering information below).
QUICK LINKS
OX2R Antibody (OX102) is a mouse monoclonal IgG1 kappa light chain antibody that detects the OX2R protein of mouse and rat origin by immunofluorescence (IF) and flow cytometry (FCM). Anti-OX2R antibody (OX102) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates, providing versatility for different experimental needs. The OX2 receptor (OX2R), also known as CD200 receptor, is a critical membrane protein that plays a significant role in immune regulation. OX2R is primarily expressed in lymphoid and neuronal tissues, where OX2R interacts with its ligand, OX2, to modulate immune responses. The cytoplasmic domain of OX2R contains NPXY motifs that facilitate interactions with phosphotyrosine-binding (PTB) domains, which are essential for downstream signaling pathways. These interactions are crucial for maintaining immune homeostasis, as OX2R helps suppress excessive macrophage activation and limits inflammatory damage in tissues. Understanding OX2R function and interactions is vital for developing therapeutic strategies aimed at controlling inflammation and autoimmune diseases.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
OX2R Antibody (OX102) References:
- Lymphoid/neuronal cell surface OX2 glycoprotein recognizes a novel receptor on macrophages implicated in the control of their function. | Wright, GJ., et al. 2000. Immunity. 13: 233-42. PMID: 10981966
- Receptor engagement on cells expressing a ligand for the tolerance-inducing molecule OX2 induces an immunoregulatory population that inhibits alloreactivity in vitro and in vivo. | Gorczynski, RM., et al. 2000. J Immunol. 165: 4854-60. PMID: 11046009
- Down-regulation of the macrophage lineage through interaction with OX2 (CD200). | Hoek, RM., et al. 2000. Science. 290: 1768-71. PMID: 11099416
- Distribution of OX2 antigen and OX2 receptor within retina. | Dick, AD., et al. 2001. Invest Ophthalmol Vis Sci. 42: 170-6. PMID: 11133863
- OX2R activation induces PKC-mediated ERK and CREB phosphorylation. | Guo, Y. and Feng, P. 2012. Exp Cell Res. 318: 2004-13. PMID: 22652455
- C-terminus of OX2R significantly affects downstream signaling pathways. | Wang, C., et al. 2017. Mol Med Rep. 16: 159-166. PMID: 28487995
- Orexin Receptor Antagonists as Emerging Treatments for Psychiatric Disorders. | Han, Y., et al. 2020. Neurosci Bull. 36: 432-448. PMID: 31782044
- Orexin 2 receptor (OX2R) protein distribution measured by autoradiography using radiolabeled OX2R-selective antagonist EMPA in rodent brain and peripheral tissues. | Mitsukawa, K. and Kimura, H. 2022. Sci Rep. 12: 8473. PMID: 35589803
- Localization and expression of Orexin B (OXB) and its type 2 receptor (OX2R) in mouse testis during postnatal development. | Yadav, A., et al. 2023. Peptides. 164: 170979. PMID: 36841281
- TAK-994, a Novel Orally Available Brain-Penetrant Orexin 2 Receptor-Selective Agonist, Suppresses Fragmentation of Wakefulness and Cataplexy-Like Episodes in Mouse Models of Narcolepsy. | Ishikawa, T., et al. 2023. J Pharmacol Exp Ther. 385: 193-204. PMID: 37001988
- The gene for MRC OX-2 membrane glycoprotein is localized on human chromosome 3. | McCaughan, GW., et al. 1987. Immunogenetics. 25: 133-5. PMID: 3817906
- Effects of an OX2R agonist on migration and removal of tau from mouse brain. | Terada, M., et al. 2024. Sci Rep. 14: 15964. PMID: 38987562
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
OX2R Antibody (OX102) | sc-53101 | 200 µg/ml | $322.00 | |||
OX2R Antibody (OX102): m-IgG Fc BP-HRP Bundle | sc-526768 | 200 µg Ab; 10 µg BP | $361.00 | |||
OX2R Antibody (OX102): m-IgG1 BP-HRP Bundle | sc-532141 | 200 µg Ab; 20 µg BP | $361.00 | |||
OX2R Antibody (OX102) AC | sc-53101 AC | 500 µg/ml, 25% agarose | $424.00 | |||
OX2R Antibody (OX102) HRP | sc-53101 HRP | 200 µg/ml | $322.00 | |||
OX2R Antibody (OX102) FITC | sc-53101 FITC | 200 µg/ml | $336.00 | |||
OX2R Antibody (OX102) PE | sc-53101 PE | 200 µg/ml | $349.00 | |||
OX2R Antibody (OX102) Alexa Fluor® 488 | sc-53101 AF488 | 200 µg/ml | $364.00 | |||
OX2R Antibody (OX102) Alexa Fluor® 546 | sc-53101 AF546 | 200 µg/ml | $364.00 | |||
OX2R Antibody (OX102) Alexa Fluor® 594 | sc-53101 AF594 | 200 µg/ml | $364.00 | |||
OX2R Antibody (OX102) Alexa Fluor® 647 | sc-53101 AF647 | 200 µg/ml | $364.00 | |||
OX2R Antibody (OX102) Alexa Fluor® 680 | sc-53101 AF680 | 200 µg/ml | $364.00 | |||
OX2R Antibody (OX102) Alexa Fluor® 790 | sc-53101 AF790 | 200 µg/ml | $364.00 |