OX2R Activators
Cell surface glycoprotein CD200 receptor 1 (CD200R1) activators encompass a range of compounds that indirectly promote the upregulation of CD200R1 through diverse signaling pathways, primarily to foster anti-inflammatory responses within the immune system. Lipopolysaccharide, despite its initial pro-inflammatory role through TLRs, may enhance CD200R1 expression as a feedback mechanism to mitigate unchecked immune activation. Similarly, specialized pro-resolving mediators such as Resolvin D1, through GPCR interaction, are known to facilitate the resolution phase of inflammation, which includes the upregulation of CD200R1 to restore homeostasis.
Other molecules like Prostaglandin E2 and Adenosine work through their respective GPCRs to increase intracellular cAMP, which in turn activates PKA, a kinase that can phosphorylate transcription factors involved in the anti-inflammatory gene expression, including that of CD200R1. This suggests a role for these molecules in enhancing the immune-regulatory function of CD200R1. Further, the activation of nuclear receptors by ligands such as Vitamin D3 and PPAR-γ agonists like Pioglitazone also leads to transcriptional changes that can favor the expression of CD200R1, thereby contributing to an anti-inflammatory phenotype in immune cells. One activator within this class is monoclonal antibody OX110, which can enhance CD200R1 signaling by binding to the CD200 ligand and preventing its interaction with CD200R1. This blockade of the CD200-CD200R1 interaction results in the disinhibition of immune responses. OX110 essentially acts as a positive modulator of CD200R1 activity, enabling a heightened immune response against target cells.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PGE2 | 363-24-6 | sc-201225 sc-201225C sc-201225A sc-201225B | 1 mg 5 mg 10 mg 50 mg | $57.00 $159.00 $275.00 $678.00 | 37 | |
Prostaglandin E2 (PGE2) interacts with its E-prostanoid receptors, which can stimulate cAMP production and activate protein kinase A (PKA). PKA signaling can lead to the up-regulation of anti-inflammatory genes, potentially including CD200R1 as a means to modulate immune cell interactions. | ||||||
Cholecalciferol | 67-97-0 | sc-205630 sc-205630A sc-205630B | 1 g 5 g 10 g | $71.00 $163.00 $296.00 | 2 | |
Vitamin D3, through its active metabolite calcitriol, binds to the vitamin D receptor (VDR), which can modulate the expression of genes involved in immune response. This may include the up-regulation of CD200R1 expression on immune cells, contributing to the immune modulatory effects of vitamin D3. | ||||||
Adenosine | 58-61-7 | sc-291838 sc-291838A sc-291838B sc-291838C sc-291838D sc-291838E sc-291838F | 1 g 5 g 100 g 250 g 1 kg 5 kg 10 kg | $34.00 $48.00 $300.00 $572.00 $1040.00 $2601.00 $4682.00 | 1 | |
Adenosine binds to adenosine receptors, which are GPCRs that can activate adenylate cyclase and increase cAMP levels. This activation can enhance the expression of anti-inflammatory markers on immune cells, including potentially CD200R1, to modulate the immune response. | ||||||
NAD+, Free Acid | 53-84-9 | sc-208084B sc-208084 sc-208084A sc-208084C sc-208084D sc-208084E sc-208084F | 1 g 5 g 10 g 25 g 100 g 1 kg 5 kg | $57.00 $191.00 $302.00 $450.00 $1800.00 $3570.00 $10710.00 | 4 | |
NAD+ can serve as a substrate for sirtuins, which are NAD+-dependent deacetylases that regulate various physiological processes including inflammation. Sirtuin activity may promote an anti-inflammatory cellular environment that enhances the expression of CD200R1. | ||||||
Pioglitazone | 111025-46-8 | sc-202289 sc-202289A | 1 mg 5 mg | $55.00 $125.00 | 13 | |
Pioglitazone, a PPAR-γ agonist, activates PPAR-γ receptors leading to the transcription of genes that promote lipid metabolism and insulin sensitivity, and can also up-regulate anti-inflammatory markers potentially including CD200R1. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $91.00 $139.00 $374.00 | 36 | |
Dexamethasone binds to glucocorticoid receptors, which translocate to the nucleus and act as transcription factors for anti-inflammatory genes. This action can lead to the up-regulation of immune-inhibitory receptors such as CD200R1. | ||||||
Thymosin β4 | 77591-33-4 | sc-396076 sc-396076A | 1 mg 100 mg | $134.00 $7140.00 | ||
TGF-β binds to its receptors and initiates the SMAD signaling pathway, which often results in the transcription of genes involved in immune suppression. This signaling can logically increase the expression of CD200R1, contributing to an anti-inflammatory cell state. | ||||||