OTUD7B Antibody (A-11): sc-514334

OTUD7B Antibody (A-11) is a mouse monoclonal IgG2b antibody that detects OTUD7B in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). OTUD7B, also known as ZA20D1 or Cezanne, is an 843 amino acid protein that plays a crucial role in regulating cellular processes by hydrolyzing branched and linear forms of polyubiquitin, specifically targeting Lys-48- and Lys-63-linked polyubiquitin chains. This deubiquitinating activity is vital for modulating the inflammatory response within cells, as OTUD7B forms a negative feedback loop in pro-inflammatory signaling pathways, effectively suppressing NFκB activity and aiding in the resolution of inflammation. OTUD7B is expressed in various tissues, including the liver, kidney, heart, and immature B-cells, and is localized in both the nucleus and cytoplasm, highlighting its importance in diverse cellular contexts. OTUD7B contains a C-terminal A20-type zinc finger, an OTU domain, and an N-terminal TRAF-binding domain, which are essential for enzymatic function and interaction with other proteins involved in signaling pathways. Anti-OTUD7B antibody (A-11) is an invaluable tool for researchers studying the intricate mechanisms of inflammation and cell survival, providing insights into potential therapeutic targets for inflammatory diseases.

The preferred OTUD7B antibody is OTUD7B Antibody (H-4): sc-514402.