Otoconin 90 Antibody (D-7): sc-376744

Otoconin 90 Antibody (D-7) is a mouse monoclonal IgG2b antibody that detects Otoconin 90 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Otoconin 90, also known as PLA2L (phospholipase A2 homolog) or OC90, is a 493 amino acid secreted protein that plays a crucial role in the formation and regulation of otoconia, the dense particles essential for the vestibular system′s ability to sense gravity and motion. Otoconin 90 consists of three phospholipase A2-type domains, which are vital for the growth and stability of otoconia crystals composed of proteins and calcium carbonate. By recruiting other matrix components, Otoconin 90 is instrumental in forming the organic matrix of otoconia, thereby ensuring the proper functioning of mechanoreceptors in the utricle and saccule, which are responsible for detecting linear acceleration and gravitational forces. The gene encoding Otoconin 90 is located on human chromosome 8, a region associated with various diseases and malignancies, highlighting Otoconin 90′s significance not only in sensory perception but also in potential pathological conditions. Anti-Otoconin 90 antibody (D-7) serves as a valuable tool for researchers investigating the molecular mechanisms underlying balance and spatial orientation.

The preferred Otoconin 90 antibody is Otoconin 90 Antibody (D-2): sc-376855.