Osteoglycin Antibody (G-1): sc-374463

Osteoglycin Antibody (G-1) is a mouse monoclonal IgG1 kappa light chain antibody that detects Osteoglycin protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Osteoglycin (G-1) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Osteoglycin, also known as Mimecan or osteoinductive factor, is a member of the small leucine-rich proteoglycan (SLRP) family, which plays a crucial role in organizing extracellular matrix and interacts with transforming growth factor beta (TGFβ) to regulate bone formation. Osteoglycin is primarily secreted and found in bone tissues, where Osteoglycin is essential for inducing bone formation in conjunction with TGFβ1 or TGFβ2. The precursor form of Osteoglycin undergoes in situ proteolytic cleavage, resulting in a mature form that is biologically active. This post-translational modification ensures proper functioning of Osteoglycin in bone development and maintenance, highlighting Osteoglycin′s importance in skeletal health and potential implications in bone-related diseases.

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Osteoglycin Antibody (G-1) References:

1. The bovine mimecan gene. Molecular cloning and characterization of two major RNA transcripts generated by alternative use of two splice acceptor sites in the third exon.  |  Tasheva, ES., et al. 1999. J Biol Chem. 274: 18693-701. PMID: 10373482
2. Mutations in KERA, encoding keratocan, cause cornea plana.  |  Pellegata, NS., et al. 2000. Nat Genet. 25: 91-5. PMID: 10802664
3. Analysis of transcriptional regulation of the small leucine rich proteoglycans.  |  Tasheva, ES., et al. 2004. Mol Vis. 10: 758-72. PMID: 15496828
4. Adsorption of serum fetuin to hydroxylapatite does not contribute to osteoblast phenotype modifications.  |  Xie, J., et al. 2005. J Biomed Mater Res A. 73: 39-47. PMID: 15714505
5. Healing of critically sized femoral defects, using genetically modified mesenchymal stem cells from human adipose tissue.  |  Peterson, B., et al. 2005. Tissue Eng. 11: 120-9. PMID: 15738667
6. Characterization of the non-collagenous proteins in avian cortical and medullary bone.  |  Wang, X., et al. 2005. Comp Biochem Physiol B Biochem Mol Biol. 140: 665-72. PMID: 15763522
7. Substrate-specific modulation of a multisubstrate proteinase. C-terminal processing of fibrillar procollagens is the only BMP-1-dependent activity to be enhanced by PCPE-1.  |  Moali, C., et al. 2005. J Biol Chem. 280: 24188-94. PMID: 15834133
8. Osteoglycin deficiency does not affect atherosclerosis in mice.  |  Moncayo-Arlandi, J., et al. 2014. Atherosclerosis. 237: 418-25. PMID: 25463067
9. Osteoglycin prevents the development of age-related diastolic dysfunction during pressure overload by reducing cardiac fibrosis and inflammation.  |  Deckx, S., et al. 2018. Matrix Biol. 66: 110-124. PMID: 28958774
10. Serum levels of iCAF-derived osteoglycin predict favorable outcome in pancreatic cancer.  |  Dings, MPG., et al. 2023. Int J Cancer. 152: 511-523. PMID: 36069222
11. Serum osteoglycin is stable during various glycemic challenges in healthy men.  |  Starup-Linde, J., et al. 2024. Endocrine. 85: 1117-1121. PMID: 38549032
12. Differential splicing and alternative polyadenylation generate multiple mimecan mRNA transcripts.  |  Tasheva, ES., et al. 1997. J Biol Chem. 272: 32551-6. PMID: 9405469

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Osteoglycin Antibody (G-1) has 10 citations in a variety of scientific publications.

Primary antibodies like Anti-Osteoglycin Antibody (G-1) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Osteoglycin Antibody (G-1) Specifications

Alternate Product Name: OGN

Product Clone Name: G-1

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 21-90

Epitope Target: Osteoglycin

Epitope Species: mouse

Product Reactivity/Detection: Osteoglycin and Osteoglycin precursor (Mimecan)

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 10 citations in various scientific publications

Available Conjugates/Forms for Osteoglycin Antibody (G-1): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin