osteocalcin Antibody (E-6): sc-376835

Osteocalcin Antibody (E-6) is a mouse monoclonal IgG1 kappa light chain antibody that detects osteocalcin, osteocalcin-2, and osteocalcin-related protein of mouse origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-osteocalcin antibody (E-6) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Osteocalcin, also known as bone γ-carboxyglutamic acid (Gla) protein, BGLAP, or BGP, is a crucial non-collagenous protein component of bone synthesized by osteoblasts. Osteocalcin binds to hydroxyapatite in a calcium-dependent manner, facilitating mineralization during bone formation. In mice, osteocalcin is encoded by a cluster of three genes—OG1, OG2, and ORG—located within a 23Kb span of genomic DNA, highlighting evolutionary conservation. The human form of osteocalcin consists of 46-50 amino acids and features three vitamin K-dependent γ-carboxyglutamic acid residues, which are essential for function. Genetic variations at the osteocalcin locus on chromosome 1q have been associated with postmenopausal bone mineral density levels, indicating potential role in osteoporosis predisposition. Osteocalcin monoclonal antibody (E-6) in multiple formats serves as an invaluable tool for researchers studying bone biology and related disorders.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-osteocalcin Antibody (E-6) has 18 citations in a variety of scientific publications.

Primary antibodies like Anti-osteocalcin Antibody (E-6) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

osteocalcin Antibody (E-6) Specifications

Alternate Product Name: osteocalcin

Product Clone Name: E-6

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 41-79

Epitope Target: osteocalcin

Epitope Species: mouse

Product Reactivity/Detection: osteocalcin, osteocalcin-2 and osteocalcin-related protein

Species Reactivity/Detection: mouse

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 18 citations in various scientific publications

Available Conjugates/Forms for osteocalcin Antibody (E-6): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin

The preferred osteocalcin antibody is osteocalcin Antibody (D-11): sc-390877.