osteocalcin Activators
Osteocalcin activators are a chemical class that can either directly or indirectly stimulate the production of Osteocalcin, a protein encoded by the BGLAP gene. Direct activators, such as Calcitriol, Retinoic Acid, and Glucocorticoids, can increase the expression of the BGLAP gene by binding to their respective receptors, which can interact with specific response elements on the gene. This class of chemicals can activate Osteocalcin production without the need for additional cellular processes, making them primary activators of the protein.
Indirect activators, on the other hand, influence the cellular processes or signaling pathways that Osteocalcin is involved in. These chemicals do not interact with the protein directly, but their action can lead to the protein's production. Insulin, Forskolin, Ascorbic Acid, Estradiol, and Testosterone fall into this category. They act by binding to their respective receptors on osteoblasts, initiating cellular signaling pathways that can ultimately increase BGLAP gene expression. The indirect activators represent a diverse group of chemicals, each affecting the Osteocalcin pathway through a unique mechanism.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
1α,25-Dihydroxyvitamin D3 | 32222-06-3 | sc-202877B sc-202877A sc-202877C sc-202877D sc-202877 | 50 µg 1 mg 5 mg 10 mg 100 µg | $220.00 $645.00 $1000.00 $1500.00 $440.00 | 32 | |
Calcitriol can increase the expression of the BGLAP gene, which encodes Osteocalcin. It achieves this by binding to vitamin D receptors (VDRs), which can interact with vitamin D response elements (VDREs) on the BGLAP gene. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic Acid can enhance BGLAP gene expression by interacting with retinoic acid receptors (RARs), which can bind to retinoic acid response elements (RAREs) on the BGLAP gene. | ||||||
Insulin | 11061-68-0 | sc-29062 sc-29062A sc-29062B | 100 mg 1 g 10 g | $156.00 $1248.00 $12508.00 | 82 | |
Insulin can increase the production of Osteocalcin by binding to insulin receptors on osteoblasts, leading to the activation of the PI3K/Akt pathway and upregulation of the BGLAP gene. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin can stimulate Osteocalcin production by increasing cAMP levels, which can activate the cAMP response element-binding (CREB) protein, leading to enhanced BGLAP gene expression. | ||||||
L-Ascorbic acid, free acid | 50-81-7 | sc-202686 | 100 g | $46.00 | 5 | |
Ascorbic Acid can increase Osteocalcin production by inducing collagen synthesis in osteoblasts, which can promote BGLAP gene expression. | ||||||
β-Estradiol | 50-28-2 | sc-204431 sc-204431A | 500 mg 5 g | $63.00 $182.00 | 8 | |
Estradiol can increase Osteocalcin production by binding to estrogen receptors on osteoblasts, activating estrogen-responsive elements, and upregulating the BGLAP gene. | ||||||