Osteocalcin Antibody (3G8) is a mouse monoclonal IgG1 antibody that detects osteocalcin in human and bovine samples through enzyme-linked immunosorbent assay (ELISA). Osteocalcin, also known as bone g-carboxyglutamic acid (Gla) protein, BGLAP, or BGP, is a crucial non-collagenous protein produced by osteoblasts and plays a significant role in bone metabolism. This highly conserved protein, consisting of 46-50 amino acids, features three vitamin K-dependent γ-carboxyglutamic acid residues, which are essential for calcium and hydroxyapatite binding during bone mineralization. Osteocalcin marks the onset of mineral deposition in bone tissue during embryonic development. As one of the most abundant proteins in mineralized adult bone, genetic variations at the osteocalcin locus on chromosome 1q have been linked to variations in postmenopausal bone mineral density (BMD), potentially influencing osteoporosis risk in women. Anti-osteocalcin antibody (3G8) serves as an invaluable tool for researchers studying bone health, mineralization processes, and genetic factors affecting bone density.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
osteocalcin Antibody (3G8) | sc-66158 | 100 µg/ml | $322.00 |