OSMR β Antibody (D-10): sc-271695

OSMR β Antibody (D-10) is a mouse monoclonal IgG1 kappa light chain antibody that detects OSMR β of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). anti-OSMR β antibody (D-10) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. OSMR β, also known as oncostatin M receptor β, is a crucial component of the signaling pathway for oncostatin M, a glycoprotein that plays a significant role in inhibiting the growth of various human tumor cell lines while sparing normal human fibroblasts. OSMR β is predominantly expressed in neural cells, as well as in fibroblast and epithelial tumor lines, and functions as a single-pass type I membrane protein that forms a heterodimer with other interleukin receptors, facilitating the transduction of OSM-induced signaling events. OSMR β′s importance extends beyond tumor biology; defects in the gene encoding OSMR β are linked to primary cutaneous amyloidosis, an autosomal dominant disorder characterized by chronic skin itching, highlighting its relevance in both cancer research and dermatological conditions.

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OSMR β Antibody (D-10) References:

1. Oncostatin M regulates the synthesis and turnover of gp130, leukemia inhibitory factor receptor alpha, and oncostatin M receptor beta by distinct mechanisms.  |  Blanchard, F., et al. 2001. J Biol Chem. 276: 47038-45. PMID: 11602599
2. Developmental expression pattern of oncostatin M receptor beta in mice.  |  Tamura, S., et al. 2002. Mech Dev. 115: 127-31. PMID: 12049776
3. Localization of oncostatin M receptor beta in adult and developing CNS.  |  Tamura, S., et al. 2003. Neuroscience. 119: 991-7. PMID: 12831858
4. Loss of oncostatin M receptor beta in metastatic melanoma cells.  |  Lacreusette, A., et al. 2007. Oncogene. 26: 881-92. PMID: 16909117
5. Complete overlap of interleukin-31 receptor A and oncostatin M receptor beta in the adult dorsal root ganglia with distinct developmental expression patterns.  |  Bando, T., et al. 2006. Neuroscience. 142: 1263-71. PMID: 16926070
6. Oncostatin M receptor-beta signaling limits monocytic cell recruitment in acute inflammation.  |  Hams, E., et al. 2008. J Immunol. 181: 2174-80. PMID: 18641356
7. Oncostatin M receptor β and cysteine/histidine-rich 1 are biomarkers of the response to erythropoietin in hemodialysis patients.  |  Merchant, ML., et al. 2011. Kidney Int. 79: 546-554. PMID: 21150872
8. Lack of oncostatin M receptor β leads to adipose tissue inflammation and insulin resistance by switching macrophage phenotype.  |  Komori, T., et al. 2013. J Biol Chem. 288: 21861-75. PMID: 23760275
9. Deficiency of oncostatin M receptor β (OSMRβ) exacerbates high-fat diet-induced obesity and related metabolic disorders in mice.  |  Komori, T., et al. 2014. J Biol Chem. 289: 13821-37. PMID: 24695736
10. A novel missense mutation in oncostatin M receptor beta causing primary localized cutaneous amyloidosis.  |  Saeedi, M., et al. 2014. Biomed Res Int. 2014: 653724. PMID: 25054142

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-OSMR β Antibody (D-10) has 6 citations in a variety of scientific publications.

Primary antibodies like Anti-OSMR β Antibody (D-10) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

OSMR β Antibody (D-10) Specifications

Alternate Product Name: OSMR β

Product Clone Name: D-10

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 780-979

Epitope Target: OSMR β

Epitope Species: human

Product Reactivity/Detection: OSMR β

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 6 citations in various scientific publications

Available Conjugates/Forms for OSMR β Antibody (D-10): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin

The preferred OSMR β antibody is OSMR β Antibody (AN-A2): sc-9992.