OSMR β Antibody (C-7): sc-376380
- OSMR β Antibody (C-7) is a mouse monoclonal IgG1 κ, cited in 1 publications, provided at 200 µg/ml
- raised against amino acids 782-971 mapping at the C-terminus of OSMR β of mouse origin
- recommended for detection of OSMR β of mouse origin by WB, IP, IF and ELISA
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for OSMR β Antibody (C-7) for WB applications. These reagents are now offered in bundles with OSMR β Antibody (C-7) (see ordering information below).
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OSMR β Antibody (C-7) is a mouse monoclonal IgG1 antibody that detects OSMR β in mouse samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). OSMR β, also known as oncostatin M receptor β, is a crucial single-pass type I membrane protein composed of 979 amino acids, primarily expressed in neural cells, fibroblasts, and various epithelial tumor lines. Anti-OSMR β antibody (C-7) plays a significant role in studying oncostatin M, a glycoprotein that influences cell growth and differentiation, particularly in hematopoietic cells. The interaction between OSMR β and interleukins is vital for transducing signaling events that can impact cellular responses, making OSMR β an important target for understanding tumor biology and immune responses. Notably, mutations in the gene encoding OSMR β are linked to primary cutaneous amyloidosis, an autosomal dominant condition characterized by chronic skin itching, highlighting the clinical relevance of this protein in disease mechanisms. OSMR β monoclonal antibody (C-7) is an essential tool for researchers investigating the complex roles of this receptor in various biological processes and disease states.
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OSMR β Antibody (C-7) References:
- Expression of oncostatin M receptor beta in a specific subset of nociceptive sensory neurons. | Tamura, S., et al. 2003. Eur J Neurosci. 17: 2287-98. PMID: 12814362
- Localization of oncostatin M receptor beta in adult and developing CNS. | Tamura, S., et al. 2003. Neuroscience. 119: 991-7. PMID: 12831858
- Lack of oncostatin M receptor β leads to adipose tissue inflammation and insulin resistance by switching macrophage phenotype. | Komori, T., et al. 2013. J Biol Chem. 288: 21861-75. PMID: 23760275
- Therapeutic targeting of the oncostatin M receptor-β prevents inflammatory heart failure. | Pöling, J., et al. 2014. Basic Res Cardiol. 109: 396. PMID: 24292852
- Deficiency of oncostatin M receptor β (OSMRβ) exacerbates high-fat diet-induced obesity and related metabolic disorders in mice. | Komori, T., et al. 2014. J Biol Chem. 289: 13821-37. PMID: 24695736
- Hepatic Oncostatin M Receptor β Regulates Obesity-Induced Steatosis and Insulin Resistance. | Luo, P., et al. 2016. Am J Pathol. 186: 1278-92. PMID: 26976243
- Oncostatin M receptor β deficiency attenuates atherogenesis by inhibiting JAK2/STAT3 signaling in macrophages. | Zhang, X., et al. 2017. J Lipid Res. 58: 895-906. PMID: 28258089
- Essential roles of oncostatin M receptor β signaling in renal crystal formation in mice. | Yamashita, S., et al. 2020. Sci Rep. 10: 17150. PMID: 33051515
- Blockade of OSMRβ signaling ameliorates skin lesions in a mouse model of human atopic dermatitis. | Komori, T., et al. 2024. FASEB J. 38: e23359. PMID: 38102969
- Suppression of renal crystal formation, inflammation, and fibrosis by blocking oncostatin M receptor β signaling. | Deguchi, R., et al. 2024. Sci Rep. 14: 28913. PMID: 39572752
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
OSMR β Antibody (C-7) | sc-376380 | 200 µg/ml | $322.00 | |||
OSMR β Antibody (C-7): m-IgG Fc BP-HRP Bundle | sc-540556 | 200 µg Ab; 10 µg BP | $361.00 | |||
OSMR β Antibody (C-7): m-IgG1 BP-HRP Bundle | sc-542204 | 200 µg Ab; 20 µg BP | $361.00 |