OSM Antibody (H-2): sc-374040

OSM Antibody (H-2) is a mouse monoclonal IgG2b antibody that detects Oncostatin M (OSM) in mouse and rat samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-OSM antibody (H-2) recognizes OSM, a glycoprotein that plays a crucial role in regulating cell growth and differentiation, particularly in hematopoietic cells. OSM (H-2) antibody detects this protein, which is primarily secreted by activated macrophages and lymphocytes, and shows elevated expression in response to inflammatory stimuli. OSM′s importance lies in its ability to inhibit the proliferation of various human tumor cell lines while sparing normal fibroblasts, making OSM a potential target for cancer therapies. Additionally, OSM shares structural homology with other key cytokines such as leukemia inhibitory factor, granulocyte colony-stimulating factor, and interleukin 6, which are all involved in the complex signaling pathways that govern immune responses and hematopoiesis. The identification of high-affinity binding sites for OSM on both normal and tumor cells underscores OSM′s significance in therapeutic applications, as this may facilitate targeted treatments that leverage OSM′s unique properties.

The preferred OSM antibody is OSM Antibody (A-9): sc-374039.