ORP150 Antibody (C-9): sc-398110

ORP150 Antibody (C-9) is a mouse monoclonal IgG1 antibody that detects ORP150 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). ORP150, also known as HYOU1 (hypoxia upregulated 1), is a 999 amino acid protein that resides in the lumen of the endoplasmic reticulum (ER) and belongs to the heat shock protein 70 (HSP 70) family. ORP150′s localization within the ER is crucial, as ORP150 plays a significant role in the proper folding and secretion of proteins, particularly in tissues with high secretory demands, such as the liver and pancreas. ORP150′s ability to assist in protein maturation is vital for maintaining cellular homeostasis, especially under conditions of stress like hypoxia, where ORP150 helps protect cells from apoptosis. Notably, ORP150 expression is often upregulated in various tumors, including breast cancer, indicating ORP150′s potential involvement in tumorigenesis and suggesting ORP150 may serve as a biomarker for cancer progression. Additionally, the gene encoding ORP150 features two translation initiation sites, leading to a truncated form that lacks an ER signal peptide but functions as a housekeeping protein in the cytoplasm, further underscoring ORP150′s versatility and importance in cellular function. Anti-ORP150 antibody (C-9) is an essential tool for researchers investigating this protein′s role in health and disease.

The preferred ORP150 antibody is ORP150 Antibody (A-3): sc-398224.