ORP-9 Antibody (A-7): sc-398961

ORP-9 Antibody (A-7) is a mouse monoclonal IgG1 kappa light chain antibody that detects ORP-9 of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). ORP-9 Antibody (A-7) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. ORP-9, a member of the oxysterol-binding protein (OSBP) family, plays a crucial role in lipid metabolism and signal transduction, as well as vesicle transport, by acting as an intracellular lipid receptor. ORP-9 is involved in the translocation to the periphery of Golgi membranes upon binding to oxysterols, which is essential for maintaining cellular lipid homeostasis and facilitating communication between organelles. ORP-9 exhibits a highly conserved OSBP-type sterol-binding region and a pleckstrin homology domain, allowing strong binding to phosphatidic acid and weak binding to phosphatidylinositol 3-phosphate. ORP-9 is widely expressed and produced in two isoforms due to alternative splicing, highlighting its functional diversity and importance in various cellular processes.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

ORP-9 Antibody (A-7) References:

1. Family of human oxysterol binding protein (OSBP) homologues. A novel member implicated in brain sterol metabolism.  |  Laitinen, S., et al. 1999. J Lipid Res. 40: 2204-11. PMID: 10588946
2. Novel members of the human oxysterol-binding protein family bind phospholipids and regulate vesicle transport.  |  Xu, Y., et al. 2001. J Biol Chem. 276: 18407-14. PMID: 11279184
3. The OSBP-related protein family in humans.  |  Lehto, M., et al. 2001. J Lipid Res. 42: 1203-13. PMID: 11483621
4. A family of 12 human genes containing oxysterol-binding domains.  |  Jaworski, CJ., et al. 2001. Genomics. 78: 185-96. PMID: 11735225
5. Identification and assessment of the role of a nominal phospholipid binding region of ORP1S (oxysterol-binding-protein-related protein 1 short) in the regulation of vesicular transport.  |  Fairn, GD. and McMaster, CR. 2005. Biochem J. 387: 889-96. PMID: 15617515
6. Oxysterol-binding protein and vesicle-associated membrane protein-associated protein are required for sterol-dependent activation of the ceramide transport protein.  |  Perry, RJ. and Ridgway, ND. 2006. Mol Biol Cell. 17: 2604-16. PMID: 16571669
7. The OSBP-related proteins (ORPs): global sterol sensors for co-ordination of cellular lipid metabolism, membrane trafficking and signalling processes?  |  Olkkonen, VM., et al. 2006. Biochem Soc Trans. 34: 389-91. PMID: 16709169

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-ORP-9 Antibody (A-7) has 5 citations in a variety of scientific publications.

Primary antibodies like Anti-ORP-9 Antibody (A-7) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

ORP-9 Antibody (A-7) Specifications

Alternate Product Name: ORP-9

Product Clone Name: A-7

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 228-379

Epitope Target: ORP-9

Epitope Species: human

Product Reactivity/Detection: ORP-9

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 5 citations in various scientific publications

Available Conjugates/Forms for ORP-9 Antibody (A-7): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin