OR4B1 Antibody (C-11): sc-376378
- OR4B1 Antibody (C-11) is a mouse monoclonal IgG1 κ OR4B1 antibody provided at 200 µg/ml
- specific for an epitope mapping between amino acids 287-319 within a C-terminal cytoplasmic domain of OR4B1 of human origin
- OR4B1 Antibody (C-11) is recommended for detection of OR4B1 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- Anti-OR4B1 Antibody (C-11) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for OR4B1 Antibody (C-11) for WB and IHC(P) applications. These reagents are now offered in bundles with OR4B1 Antibody (C-11) (see ordering information below).
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OR4B1 Antibody (C-11) is a mouse monoclonal IgG1 kappa light chain antibody that detects OR4B1 of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). OR4B1 (C-11) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. OR4B1, also known as Olfactory receptor 4B1 or Olfactory receptor OR11-106, is a 309 amino acid multi-pass membrane protein that plays a crucial role in the olfactory system by functioning as an odorant receptor. Located in the cilia of olfactory sensory neurons, OR4B1 binds to a diverse array of odor molecules, initiating a signal transduction cascade that results in the production of cyclic adenosine monophosphate (cAMP) through an olfactory-enriched adenylate cyclase. This process is vital for the transmission of action potentials to the brain, ultimately leading to the perception of smell. The genes encoding olfactory receptors, including OR4B1, represent the largest family in the human genome, highlighting their importance in sensory perception and environmental interaction.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
OR4B1 Antibody (C-11) References:
- Functional identification and reconstitution of an odorant receptor in single olfactory neurons. | Touhara, K., et al. 1999. Proc Natl Acad Sci U S A. 96: 4040-5. PMID: 10097159
- Functional cloning and reconstitution of vertebrate odorant receptors. | Touhara, K. 2001. Life Sci. 68: 2199-206. PMID: 11358328
- Molecular bases of odor discrimination: Reconstitution of olfactory receptors that recognize overlapping sets of odorants. | Kajiya, K., et al. 2001. J Neurosci. 21: 6018-25. PMID: 11487625
- Odor discrimination by G protein-coupled olfactory receptors. | Touhara, K. 2002. Microsc Res Tech. 58: 135-41. PMID: 12203691
- The human olfactory receptor gene family. | Malnic, B., et al. 2004. Proc Natl Acad Sci U S A. 101: 2584-9. PMID: 14983052
- Better smelling through genetics: mammalian odor perception. | Keller, A. and Vosshall, LB. 2008. Curr Opin Neurobiol. 18: 364-9. PMID: 18938244
- Olfactory receptor signaling. | Antunes, G. and Simoes de Souza, FM. 2016. Methods Cell Biol. 132: 127-45. PMID: 26928542
- Olfactory receptor OR2AT4 regulates human hair growth. | Chéret, J., et al. 2018. Nat Commun. 9: 3624. PMID: 30228264
- Epigenetic programming of stochastic olfactory receptor choice. | Yusuf, N. and Monahan, K. 2024. Genesis. 62: e23593. PMID: 38562011
- Odorant receptor diversity and patterned gene expression in the mammalian olfactory epithelium. | Sullivan, SL., et al. 1994. Prog Clin Biol Res. 390: 75-84. PMID: 7724652
- Receptor diversity and spatial patterning in the mammalian olfactory system. | Buck, LB. 1993. Ciba Found Symp. 179: 51-64; discussion 64-7, 88-96. PMID: 8168382
- Information processing in mammalian olfactory system. | Sullivan, SL. and Dryer, L. 1996. J Neurobiol. 30: 20-36. PMID: 8727980
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
OR4B1 Antibody (C-11) | sc-376378 | 200 µg/ml | $322.00 | |||
OR4B1 Antibody (C-11): m-IgGκ BP-HRP Bundle | sc-522936 | 200 µg Ab, 40 µg BP | $361.00 | |||
OR4B1 Antibody (C-11): m-IgG1 BP-HRP Bundle | sc-533537 | 200 µg Ab; 20 µg BP | $361.00 | |||
OR4B1 Antibody (C-11) AC | sc-376378 AC | 500 µg/ml, 25% agarose | $424.00 | |||
OR4B1 Antibody (C-11) HRP | sc-376378 HRP | 200 µg/ml | $322.00 | |||
OR4B1 Antibody (C-11) FITC | sc-376378 FITC | 200 µg/ml | $336.00 | |||
OR4B1 Antibody (C-11) PE | sc-376378 PE | 200 µg/ml | $349.00 | |||
OR4B1 Antibody (C-11) Alexa Fluor® 488 | sc-376378 AF488 | 200 µg/ml | $364.00 | |||
OR4B1 Antibody (C-11) Alexa Fluor® 546 | sc-376378 AF546 | 200 µg/ml | $364.00 | |||
OR4B1 Antibody (C-11) Alexa Fluor® 594 | sc-376378 AF594 | 200 µg/ml | $364.00 | |||
OR4B1 Antibody (C-11) Alexa Fluor® 647 | sc-376378 AF647 | 200 µg/ml | $364.00 | |||
OR4B1 Antibody (C-11) Alexa Fluor® 680 | sc-376378 AF680 | 200 µg/ml | $364.00 | |||
OR4B1 Antibody (C-11) Alexa Fluor® 790 | sc-376378 AF790 | 200 µg/ml | $364.00 | |||
OR4B1 (C-11) Neutralizing Peptide | sc-376378 P | 100 µg/0.5 ml | $69.00 |