Date published: 2026-4-1

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OR4B1 Inhibitors

OR4B1 Inhibitors encompass a set of compounds that can directly interfere with the function of the OR4B1 olfactory receptor. These inhibitors work by various mechanisms to prevent the binding and activation of OR4B1 by its natural ligands. Some compounds, such as 2-Octynoic acid and Methyl anthranilate, function as competitive antagonists, occupying the ligand-binding site of OR4B1 and blocking the interaction with endogenous odorant molecules. These antagonists ensure that the receptor remains inactive even in the presence of its natural ligands, effectively inhibiting its function. Other inhibitors operate by modifying the receptor structure or its cellular environment. Thioacetamide, for instance, can alter the cysteine residues crucial for the receptor's ligand-binding ability. Similarly, Copper sulfate can interact with histidine residues, potentially inducing conformational changes that reduce receptor activity. Compounds like Diethyl phthalate and Eugenol may bind to hydrophobic pockets within the receptor or act as allosteric modulators, respectively, influencing OR4B1's shape and function. This allosteric modulation can either prevent the natural ligand from binding or reduce the receptor's response to ligand binding. Chemicals such as Methyl salicylate, Limonene, and Cinnamaldehyde are thought to occupy the ligand-binding site or modulate receptor activity in such a way that inhibits the normal signaling cascade initiated by OR4B1 activation.
Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Thioacetamide

62-55-5sc-213031
25 g
$54.00
(1)

A chemical that may modify the cysteine residues in the OR4B1 binding site, altering the receptor conformation and preventing ligand binding, thus inhibiting OR4B1 activation.

Copper(II) sulfate

7758-98-7sc-211133
sc-211133A
sc-211133B
100 g
500 g
1 kg
$46.00
$122.00
$189.00
3
(1)

A metal ion that can bind to histidine residues in olfactory receptors like OR4B1, potentially leading to a conformational change that reduces receptor activation.

Diethyl phthalate

84-66-2sc-239738
sc-239738A
25 ml
500 ml
$27.00
$33.00
(0)

A plasticizer that can bind to hydrophobic pockets within OR4B1, potentially interfering with the receptor's ability to bind to its natural ligands and causing inhibition.

Eugenol

97-53-0sc-203043
sc-203043A
sc-203043B
1 g
100 g
500 g
$32.00
$62.00
$218.00
2
(1)

A natural aromatic compound that may act as a competitive antagonist or allosteric modulator for OR4B1, blocking the activation of the receptor by its endogenous ligands.

Methyl Salicylate

119-36-8sc-204802
sc-204802A
250 ml
500 ml
$47.00
$70.00
(1)

An organic ester that could bind to OR4B1 and act as a competitive antagonist, preventing activation of the receptor by its natural ligand.

D-Limonene

5989-27-5sc-205283
sc-205283A
100 ml
500 ml
$84.00
$129.00
3
(1)

A common terpene that could serve as a competitive antagonist or partial agonist for OR4B1, which would inhibit the full activation of the receptor by its natural ligands.

Cinnamic Aldehyde

104-55-2sc-294033
sc-294033A
100 g
500 g
$104.00
$228.00
(0)

An aldehyde that can bind to OR4B1 and potentially act as a competitive antagonist, inhibiting the receptor's normal response to its specific activating ligands.

(±)-Menthol

89-78-1sc-250299
sc-250299A
100 g
250 g
$39.00
$68.00
(0)

A monocyclic terpene alcohol that may bind to and inhibit OR4B1 by causing a cooling sensation, which can interfere with the receptor's normal ligand-induced activation.

Capsaicin

404-86-4sc-3577
sc-3577C
sc-3577D
sc-3577A
50 mg
250 mg
500 mg
1 g
$96.00
$160.00
$240.00
$405.00
26
(1)

An active component of chili peppers that may interact with a subset of olfactory receptors, including OR4B1, leading to an allosteric modulation that inhibits receptor activation.

Isopentyl acetate

123-92-2sc-250190
sc-250190A
100 ml
500 ml
$107.00
$225.00
(0)

A flavor and fragrance agent that potentially acts as a competitive antagonist to OR4B1, inhibiting the receptor's response to its endogenous activating ligands.