Oma1 Antibody (H-11): sc-515788

Oma1 Antibody (H-11) is a mouse monoclonal IgG2b kappa light chain antibody that detects the Oma1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). anti-Oma1 antibody (H-11) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Oma1, also known as OMA1 homolog, zinc metallopeptidase, is a 521 amino acid mitochondrial protease that plays a crucial role in the quality control of mitochondrial proteins by mediating the proteolytic breakdown of misfolded derivatives of the polytopic inner membrane protein OXA1. This function is vital for maintaining mitochondrial integrity and function, as the accumulation of misfolded proteins can lead to mitochondrial dysfunction and contribute to various diseases. The gene encoding Oma1 is located on human chromosome 1, which harbors numerous disease-associated genes and is implicated in various conditions, including familial adenomatous polyposis, Parkinson′s disease, and several cancers. Oma1 (H-11) monoclonal antibody enables researchers to gain insights into mitochondrial quality control mechanisms and their implications in health and disease.

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Oma1 Antibody (H-11) References:

1. Schizophrenia and affective disorders--cosegregation with a translocation at chromosome 1q42 that directly disrupts brain-expressed genes: clinical and P300 findings in a family.  |  Blackwood, DH., et al. 2001. Am J Hum Genet. 69: 428-33. PMID: 11443544
2. Identification of a human cDNA sequence which encodes a novel membrane-associated protein containing a zinc metalloprotease motif.  |  Bao, YC., et al. 2003. DNA Res. 10: 123-8. PMID: 12886954
3. Oma1, a novel membrane-bound metallopeptidase in mitochondria with activities overlapping with the m-AAA protease.  |  Kaser, M., et al. 2003. J Biol Chem. 278: 46414-23. PMID: 12963738
4. New insights into the evolution of chromosome 1.  |  Weise, A., et al. 2005. Cytogenet Genome Res. 108: 217-22. PMID: 15545733
5. Protein O-mannosylation is crucial for cell wall integrity, septation and viability in fission yeast.  |  Willer, T., et al. 2005. Mol Microbiol. 57: 156-70. PMID: 15948957
6. Mitochondrial signal peptidases of yeast: the rhomboid peptidase Pcp1 and its substrate cytochrome C peroxidase.  |  Michaelis, G., et al. 2005. Gene. 354: 58-63. PMID: 15979251
7. Proteolytic activity of HtpX, a membrane-bound and stress-controlled protease from Escherichia coli.  |  Sakoh, M., et al. 2005. J Biol Chem. 280: 33305-10. PMID: 16076848
8. Chromosome 1 abnormalities in multiple myeloma.  |  Marzin, Y., et al. 2006. Anticancer Res. 26: 953-9. PMID: 16619492
9. Mitochondrial stress is relayed to the cytosol by an OMA1-DELE1-HRI pathway.  |  Guo, X., et al. 2020. Nature. 579: 427-432. PMID: 32132707
10. OMA1 reprograms metabolism under hypoxia to promote colorectal cancer development.  |  Wu, Z., et al. 2021. EMBO Rep. 22: e50827. PMID: 33314701
11. OMA1-mediated integrated stress response protects against ferroptosis in mitochondrial cardiomyopathy.  |  Ahola, S., et al. 2022. Cell Metab. 34: 1875-1891.e7. PMID: 36113464
12. Families of zinc metalloproteases.  |  Hooper, NM. 1994. FEBS Lett. 354: 1-6. PMID: 7957888

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Oma1 Antibody (H-11) has 43 citations in a variety of scientific publications.

Primary antibodies like Anti-Oma1 Antibody (H-11) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Oma1 Antibody (H-11) Specifications

Alternate Product Name: Oma1

Product Clone Name: H-11

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b kappa light chain

Amino Acids: 230-399

Epitope Target: Oma1

Epitope Species: human

Product Reactivity/Detection: Oma1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG_2b kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 43 citations in various scientific publications

Available Conjugates/Forms for Oma1 Antibody (H-11): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin