OLIG1 Antibody (A-2): sc-373679

OLIG1 Antibody (A-2) is a mouse monoclonal IgG2b antibody that detects OLIG1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). OLIG1 is a member of the oligodendrocyte lineage-specific basic helix-loop-helix (OLIG) family of transcription factors, which play a crucial role in the regulation of oligodendrogenesis, particularly in the development of oligodendrocytes in the nervous system. OLIG1 is predominantly expressed in nervous tissue, where anti-OLIG1 antibody (A-2) helps detect its function as a key regulator of gene expression during the formation of oligodendrocytes, essential for myelination and proper neuronal function. Notably, OLIG1 interacts with Nkx-2.2, a homeodomain protein that influences ventral neuronal patterning in the embryonic neural tube, thereby affecting the differentiation of various neuronal cell types. OLIG1 expression, along with OLIG2, is significantly elevated in oligodendroglioma, a type of brain tumor, while being nearly absent in astrocytomas, highlighting OLIG1 monoclonal antibody (A-2) potential as a molecular marker for glial brain tumors, which are the most prevalent primary malignancies in the human brain. Anti-OLIG1 antibody (A-2) serves as an invaluable tool for researchers investigating oligodendrocyte biology and related pathologies.

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OLIG1 Antibody (A-2) References:

1. Ectopic expression of Olig1 promotes oligodendrocyte formation and reduces neuronal survival in developing mouse cortex.  |  Lu, QR., et al. 2001. Nat Neurosci. 4: 973-4. PMID: 11574831
2. Expression of the oligodendroglial lineage-associated markers Olig1 and Olig2 in different types of human gliomas.  |  Ohnishi, A., et al. 2003. J Neuropathol Exp Neurol. 62: 1052-9. PMID: 14575240
3. Olig1 is downregulated in oligodendrocyte progenitor cell differentiation.  |  Gong, X., et al. 2008. Neuroreport. 19: 1203-7. PMID: 18628665
4. Progesterone attenuates neurological behavioral deficits of experimental autoimmune encephalomyelitis through remyelination with nucleus-sublocalized Olig1 protein.  |  Yu, HJ., et al. 2010. Neurosci Lett. 476: 42-5. PMID: 20381586
5. Olig1 is expressed in human oligodendrocytes during maturation and regeneration.  |  Othman, A., et al. 2011. Glia. 59: 914-26. PMID: 21446039
6. Olig1 function is required for remyelination potential of transplanted neural progenitor cells in a model of viral-induced demyelination.  |  Whitman, LM., et al. 2012. Exp Neurol. 235: 380-7. PMID: 22449475
7. Oligodendrocyte transcription factor 1 (Olig1) is a Smad cofactor involved in cell motility induced by transforming growth factor-β.  |  Motizuki, M., et al. 2013. J Biol Chem. 288: 18911-22. PMID: 23720758
8. TIP30 inhibits oligodendrocyte precursor cell differentiation via cytoplasmic sequestration of Olig1.  |  Yang, W., et al. 2015. Glia. 63: 684-98. PMID: 25530119
9. Identification of CRYAB+ KCNN3+ SOX9+ Astrocyte-Like and EGFR+ PDGFRA+ OLIG1+ Oligodendrocyte-Like Tumoral Cells in Diffuse IDH1-Mutant Gliomas and Implication of NOTCH1 Signalling in Their Genesis.  |  Augustus, M., et al. 2021. Cancers (Basel). 13: PMID: 33925547
10. The Shh/Gli1 signaling pathway regulates regeneration via transcription factor Olig1 expression after focal cerebral ischemia in rats.  |  Zhao, H., et al. 2022. Neurol Res. 44: 318-330. PMID: 34592910

The preferred OLIG1 antibody is OLIG1 Antibody (G-3): sc-166256.