Odin Antibody (F-9): sc-398547
- Odin Antibody (F-9) is a mouse monoclonal IgG1 κ Odin antibody provided at 200 µg/ml
- raised against amino acids 731-808 mapping within an internal region of Odin of human origin
- Odin Antibody (F-9) is recommended for detection of Odin of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-Odin Antibody (F-9) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for Odin Antibody (F-9) for WB applications. These reagents are now offered in bundles with Odin Antibody (F-9) (see ordering information below).
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Odin Antibody (F-9) is a mouse monoclonal IgG1 kappa light chain antibody that detects Odin protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-Odin antibody (F-9) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Odin protein, also known as ANKS1A, consists of 1,134 amino acids and plays a crucial role in cellular signaling, particularly in regulating growth factor receptor pathways. Odin (F-9) antibody recognizes a protein that acts as a negative regulator of these pathways, influencing cell proliferation and differentiation. Odin undergoes phosphorylation on tyrosine residues in response to growth factors such as epidermal growth factor (EGF) and platelet-derived growth factor (PDGF), but does not respond to cytokines like interleukin-3 or erythropoietin. Odin protein is primarily located in the cytoplasm, both before and after growth factor treatment, and is widely expressed across various tissues. Structurally, Odin contains six ankyrin repeats, one phosphotyrosine-binding domain, and two sterile alpha motif domains, which are essential for interactions and regulatory functions. Odin protein has been shown to inhibit EGF-induced activation of the FOS promoter when overexpressed, highlighting a role in modulating signaling pathways. ANKS1A gene encoding Odin is located on chromosome 6p21.31, underscoring genetic significance in cellular processes.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Odin Antibody (F-9) References:
- Cloning of a novel phosphotyrosine binding domain containing molecule, Odin, involved in signaling by receptor tyrosine kinases. | Pandey, A., et al. 2002. Oncogene. 21: 8029-36. PMID: 12439753
- The DNA sequence and analysis of human chromosome 6. | Mungall, AJ., et al. 2003. Nature. 425: 805-11. PMID: 14574404
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). | Gerhard, DS., et al. 2004. Genome Res. 14: 2121-7. PMID: 15489334
- Mouse embryonic fibroblasts derived from Odin deficient mice display a hyperproliiferative phenotype. | Kristiansen, TZ., et al. 2004. DNA Res. 11: 285-92. PMID: 15500253
- Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain. | Nagase, T., et al. 1996. DNA Res. 3: 321-9, 341-54. PMID: 9039502
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Odin Antibody (F-9) | sc-398547 | 200 µg/ml | $322.00 | |||
Odin Antibody (F-9): m-IgG Fc BP-HRP Bundle | sc-530840 | 200 µg Ab; 10 µg BP | $361.00 | |||
Odin Antibody (F-9): m-IgGκ BP-HRP Bundle | sc-524386 | 200 µg Ab, 40 µg BP | $361.00 | |||
Odin Antibody (F-9): m-IgG1 BP-HRP Bundle | sc-544274 | 200 µg Ab; 20 µg BP | $361.00 | |||
Odin Antibody (F-9) AC | sc-398547 AC | 500 µg/ml, 25% agarose | $424.00 | |||
Odin Antibody (F-9) HRP | sc-398547 HRP | 200 µg/ml | $322.00 | |||
Odin Antibody (F-9) FITC | sc-398547 FITC | 200 µg/ml | $336.00 | |||
Odin Antibody (F-9) PE | sc-398547 PE | 200 µg/ml | $349.00 | |||
Odin Antibody (F-9) Alexa Fluor® 488 | sc-398547 AF488 | 200 µg/ml | $364.00 | |||
Odin Antibody (F-9) Alexa Fluor® 546 | sc-398547 AF546 | 200 µg/ml | $364.00 | |||
Odin Antibody (F-9) Alexa Fluor® 594 | sc-398547 AF594 | 200 µg/ml | $364.00 | |||
Odin Antibody (F-9) Alexa Fluor® 647 | sc-398547 AF647 | 200 µg/ml | $364.00 | |||
Odin Antibody (F-9) Alexa Fluor® 680 | sc-398547 AF680 | 200 µg/ml | $364.00 | |||
Odin Antibody (F-9) Alexa Fluor® 790 | sc-398547 AF790 | 200 µg/ml | $364.00 |