Oct-1 Antibody (E-8): sc-28334
- Oct-1 Antibody (E-8) is a mouse monoclonal IgM κ, cited in 3 publications, provided at 200 µg/ml
- raised against amino acids 679-743 of Oct-1 of human origin
- recommended for detection of Oct-1 of human origin by WB, IP, IF and ELISA
- TransCruz reagent for Gel Supershift and ChIP applications (sc-28334 X, 200 µg/0.1 ml)
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Oct-1 Antibody (E-8). This work is in progress.
QUICK LINKS
Oct-1 Antibody (E-8) is a mouse monoclonal IgM antibody that detects Oct-1 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Oct-1, a member of the POU domain family of transcription factors, plays a crucial role in regulating gene expression by binding to specific DNA sequences known as octamer motifs, which are vital for the transcription of various genes, including those involved in immune responses and cellular differentiation. Oct-1′s ability to form dimers, particularly with the transcriptional co-activator OBF1, enhances regulatory capacity, allowing Oct-1 to influence tissue-specific gene expression. This is particularly important in the context of immunoglobulin gene transcription, where Oct-1′s interaction with octamer elements is essential for proper activation of immunoglobulin promoters. Oct-1 is ubiquitously expressed across different cell types, highlighting a fundamental role in maintaining cellular functions and responding to developmental cues. With versatile binding capabilities and regulatory functions, Oct-1 is integral to both housekeeping and tissue-specific gene transcription, making anti-Oct-1 antibody (E-8) an invaluable tool for researchers studying gene regulation and expression in human cells.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Oct-1 Antibody (E-8) References:
- OCT-1 function varies with cell lineage but is not influenced by BCR-ABL. | Engler, JR., et al. 2011. Haematologica. 96: 213-20. PMID: 20971815
- Oct-1 functions as a sensor for metabolic and stress signals. | Wang, P. and Jin, T. 2010. Islets. 2: 46-8. PMID: 21099293
- OCT-1, ABCB1, and ABCG2 Expression in Imatinib-Resistant Chronic Myeloid Leukemia Treated with Dasatinib or Nilotinib. | Kim, YK., et al. 2014. Chonnam Med J. 50: 102-11. PMID: 25568846
- Expression of organic cation transporter 1 (OCT1): unique patterns of indirect regulation by nuclear receptors and hepatospecific gene regulation. | Hyrsova, L., et al. 2016. Drug Metab Rev. 48: 139-58. PMID: 27278216
- CKIP-1 limits foam cell formation and inhibits atherosclerosis by promoting degradation of Oct-1 by REGγ. | Fan, J., et al. 2019. Nat Commun. 10: 425. PMID: 30683852
- OCT-1 Expression in Patients with Chronic Myeloid Leukemia: A Comparative Analysis with Respect to Response to Imatinib Treatment. | Bozkurt Bulakcı, B., et al. 2022. Indian J Hematol Blood Transfus. 38: 668-674. PMID: 36258734
- Combined and independent effects of OCT1 and CYP2D6 on the cellular disposition of drugs. | Gebauer, L., et al. 2023. Biomed Pharmacother. 161: 114454. PMID: 36871537
- Ang II Promotes ET-1 Production by Regulating NOX2 Activity Through Transcription Factor Oct-1. | Kamhieh-Milz, J., et al. 2023. Arterioscler Thromb Vasc Biol. 43: 1429-1440. PMID: 37381986
- Neuronal miR-9 promotes HSV-1 epigenetic silencing and latency by repressing Oct-1 and Onecut family genes. | Deng, Y., et al. 2024. Nat Commun. 15: 1991. PMID: 38443365
- Mouse Oct-1 contains a composite homeodomain of human Oct-1 and Oct-2. | Suzuki, N., et al. 1993. Nucleic Acids Res. 21: 245-52. PMID: 8441632
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Oct-1 Antibody (E-8) | sc-28334 | 200 µg/ml | $322.00 | |||
Oct-1 Antibody (E-8) X | sc-28334 X | 200 µg/0.1 ml | $322.00 |