Oct-1 Antibody (0.T.100): sc-71744

Oct-1 Antibody (0.T.100) is a mouse monoclonal IgG1 antibody that detects Oct-1 in mouse, rat, and human samples through applications such as western blotting (WB) and immunoprecipitation (IP). Oct-1, a member of the POU domain family of transcription factors, plays a crucial role in regulating gene expression by binding to specific DNA sequences known as octamer motifs, which are vital for the transcription of various genes, including those involved in immune responses and cellular differentiation. Oct-1′s ability to form dimers, particularly with the transcriptional co-activator OBF1, enhances regulatory capacity, allowing Oct-1 to influence tissue-specific gene expression. This is particularly important in the context of immunoglobulin gene transcription, where Oct-1′s interaction with octamer elements is essential for proper activation of genes necessary for B cell function. Oct-1′s presence in nuclear extracts from all cell types underscores a fundamental role in cellular processes, making anti-Oct-1 antibody (0.T.100) an invaluable tool for researchers studying transcriptional regulation and its implications in various biological contexts.

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Oct-1 Antibody (0.T.100) References:

1. The regulation of the Oct-1 gene transcription is mediated by two promoters.  |  Pankratova, EV., et al. 2003. Immunol Lett. 88: 15-20. PMID: 12853155
2. Analysis of transcription factor OCT.1, OCT.2 and BOB.1 expression using tissue arrays in classical Hodgkin's lymphoma.  |  García-Cosío, M., et al. 2004. Mod Pathol. 17: 1531-8. PMID: 15257313
3. Human promoter mutations unveil Oct-1 and GATA-1 opposite action on Gfi1b regulation.  |  Hernández, A., et al. 2010. Ann Hematol. 89: 759-65. PMID: 20143233
4. Nilotinib does not significantly reduce imatinib OCT-1 activity in either cell lines or primary CML cells.  |  Eadie, L., et al. 2010. Leukemia. 24: 855-7. PMID: 20147980
5. Collaborative interaction of Oct-2 with Oct-1 in transactivation of lactogenic hormones-induced β-casein gene expression in mammary epithelial cells.  |  Qian, X. and Zhao, FQ. 2014. Gen Comp Endocrinol. 204: 185-94. PMID: 24861805
6. Oct-2 forms a complex with Oct-1 on the iNOS promoter and represses transcription by interfering with recruitment of RNA PolII by Oct-1.  |  Bentrari, F., et al. 2015. Nucleic Acids Res. 43: 9757-65. PMID: 26271992
7. Oct-1 modifies S100A4 exchange between intra- and extracellular compartments in Namalwa cells and increases their sensitivity to glucocorticoids.  |  Dukhanina, EA., et al. 2016. Cell Cycle. 15: 1471-8. PMID: 27096393
8. Pharmacokinetics of Organic Cation Transporter 1 (OCT1) Substrates in Oct1/2 Knockout Mice and Species Difference in Hepatic OCT1-Mediated Uptake.  |  Morse, BL., et al. 2020. Drug Metab Dispos. 48: 93-105. PMID: 31771949
9. Mechanisms of Sorafenib Resistance in HCC Culture Relate to the Impaired Membrane Expression of Organic Cation Transporter 1 (OCT1).  |  Chava, S., et al. 2024. J Hepatocell Carcinoma. 11: 839-855. PMID: 38741679
10. The adenovirus DNA binding protein effects the kinetics of DNA replication by a mechanism distinct from NFI or Oct-1.  |  Mul, YM. and van der Vliet, PC. 1993. Nucleic Acids Res. 21: 641-7. PMID: 8441675

The preferred Oct-1 antibody is Oct-1 Antibody (12F11): sc-8024.