OAS3 Antibody (D-7): sc-398225
- OAS3 Antibody (D-7) is a mouse monoclonal IgG1 κ OAS3 antibody, cited in 3 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 2-29 at the N-terminus of OAS3 of mouse origin
- OAS3 Antibody (D-7) is recommended for detection of OAS3 of mouse and rat origin by WB, IP, IF and ELISA
- Anti-OAS3 Antibody (D-7) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- TransCruz reagent for ChIP application (sc-398225 X, 200 µg/0.1 ml)
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for OAS3 Antibody (D-7) for WB applications. These reagents are now offered in bundles with OAS3 Antibody (D-7) (see ordering information below).
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OAS3 Antibody (D-7) is a mouse monoclonal IgG1 kappa light chain antibody that detects OAS3 protein of mouse and rat origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). OAS3 (D-7) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. The 2′-5′-oligoadenylate synthetase (OAS) family, which includes OAS3, is crucial for the cellular response to viral infections, as these proteins are induced by interferons and play a vital role in the antiviral defense mechanism. OAS3, also known as p100, is characterized by three adjacent OAS1-like domains and is located on human chromosome 12q24.2. OAS3 functions by converting ATP into 2′-5′-linked oligomers of adenosine in the presence of double-stranded RNA and magnesium ions, thereby inhibiting cellular protein synthesis and promoting apoptosis in infected cells. OAS3 enzymatic activity can be inhibited by metal ions such as copper, iron, and zinc, while manganese ions can serve as a substitute for magnesium, highlighting the importance of metal ion availability in regulating OAS activity. The OAS family, including OAS3, is essential for enhancing resistance to viral infections, making OAS3 a significant target for research in virology and therapeutic development.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
OAS3 Antibody (D-7) References:
- Gene structure of the murine 2'-5'-oligoadenylate synthetase family. | Eskildsen, S., et al. 2002. Cell Mol Life Sci. 59: 1212-22. PMID: 12222967
- Genomic structure of the mouse 2',5'-oligoadenylate synthetase gene family. | Kakuta, S., et al. 2002. J Interferon Cytokine Res. 22: 981-93. PMID: 12396720
- Characterization of the 2'-5'-oligoadenylate synthetase ubiquitin-like family. | Eskildsen, S., et al. 2003. Nucleic Acids Res. 31: 3166-73. PMID: 12799444
- Interaction between the 2'-5' oligoadenylate synthetase-like protein p59 OASL and the transcriptional repressor methyl CpG-binding protein 1. | Andersen, JB., et al. 2004. Eur J Biochem. 271: 628-36. PMID: 14728690
- Variation in antiviral 2',5'-oligoadenylate synthetase (2'5'AS) enzyme activity is controlled by a single-nucleotide polymorphism at a splice-acceptor site in the OAS1 gene. | Bonnevie-Nielsen, V., et al. 2005. Am J Hum Genet. 76: 623-33. PMID: 15732009
- Type 1 diabetes and the OAS gene cluster: association with splicing polymorphism or haplotype? | Tessier, MC., et al. 2006. J Med Genet. 43: 129-32. PMID: 16014697
- Identification of 69-kd and 100-kd forms of 2-5A synthetase in interferon-treated human cells by specific monoclonal antibodies. | Hovanessian, AG., et al. 1987. EMBO J. 6: 1273-80. PMID: 2440675
- Induction of 2.5 OAS gene expression and activity is not sufficient for IFN-gamma-induced neuroblastoma cell differentiation. | Corrias, MV., et al. 1995. Int J Cancer. 62: 223-9. PMID: 7622300
- The human 2',5'-oligoadenylate synthetase locus is composed of three distinct genes clustered on chromosome 12q24.2 encoding the 100-, 69-, and 40-kDa forms. | Hovnanian, A., et al. 1998. Genomics. 52: 267-77. PMID: 9790745
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
OAS3 Antibody (D-7) | sc-398225 | 200 µg/ml | $322.00 | |||
OAS3 Antibody (D-7): m-IgG Fc BP-HRP Bundle | sc-527753 | 200 µg Ab; 10 µg BP | $361.00 | |||
OAS3 Antibody (D-7): m-IgG1 BP-HRP Bundle | sc-533126 | 200 µg Ab; 20 µg BP | $361.00 | |||
OAS3 Antibody (D-7) X | sc-398225 X | 200 µg/0.1 ml | $322.00 | |||
OAS3 Antibody (D-7) AC | sc-398225 AC | 500 µg/ml, 25% agarose | $424.00 | |||
OAS3 Antibody (D-7) HRP | sc-398225 HRP | 200 µg/ml | $322.00 | |||
OAS3 Antibody (D-7) FITC | sc-398225 FITC | 200 µg/ml | $336.00 | |||
OAS3 Antibody (D-7) PE | sc-398225 PE | 200 µg/ml | $349.00 | |||
OAS3 Antibody (D-7) Alexa Fluor® 488 | sc-398225 AF488 | 200 µg/ml | $364.00 | |||
OAS3 Antibody (D-7) Alexa Fluor® 546 | sc-398225 AF546 | 200 µg/ml | $364.00 | |||
OAS3 Antibody (D-7) Alexa Fluor® 594 | sc-398225 AF594 | 200 µg/ml | $364.00 | |||
OAS3 Antibody (D-7) Alexa Fluor® 647 | sc-398225 AF647 | 200 µg/ml | $364.00 | |||
OAS3 Antibody (D-7) Alexa Fluor® 680 | sc-398225 AF680 | 200 µg/ml | $364.00 | |||
OAS3 Antibody (D-7) Alexa Fluor® 790 | sc-398225 AF790 | 200 µg/ml | $364.00 | |||
OAS3 (D-7) Neutralizing Peptide | sc-398225 P | 100 µg/0.5 ml | $69.00 |