OAS2 Antibody (C-1): sc-374238

OAS2 Antibody (C-1) is a mouse monoclonal IgG1 antibody that detects OAS2 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). OAS2, a member of the 2′-5′-oligoadenylate synthetase family, plays a crucial role in the cellular response to viral infections by synthesizing 2′-5′-linked oligoadenylates from ATP in the presence of double-stranded RNA and magnesium ions. This enzymatic activity is vital for inhibiting protein synthesis in infected cells, thereby limiting viral replication. OAS2 is predominantly located in the cytoplasm, where OAS2 interacts with various cellular components to mediate antiviral responses. Notably, OAS2 functions as a dimer, with its structure comprising two OAS1-homologous domains linked by a proline-rich region, which is essential for its enzymatic activity. Dysregulation of OAS2 expression has been associated with autoimmune conditions, such as lupus, highlighting its importance in both viral defense and immune system regulation. Anti-OAS2 antibody (C-1) is an invaluable tool for researchers studying these critical pathways in human health and disease.

The preferred OAS2 antibody is OAS2 Antibody (G-9): sc-271117.