Oas1a Antibody (E-2): sc-365072
- Oas1a Antibody (E-2) is a mouse monoclonal IgG2a κ, cited in 7 publications, provided at 200 µg/ml
- raised against amino acids 308-367 mapping at the C-terminus of Oas1a of mouse origin
- Anti-Oas1a Antibody (E-2) is recommended for detection of Oas1a of mouse and rat origin by WB, IP, IF, IHC(P) and ELISA
- Anti-Oas1a Antibody (E-2) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- TransCruz reagent for ChIP application (sc-365072 X, 200 µg/0.1 ml)
- m-IgG Fc BP-HRP and m-IgG2a BP-HRP are the preferred secondary detection reagents for Oas1a Antibody (E-2) for WB and IHC(P) applications. These reagents are now offered in bundles with Oas1a Antibody (E-2) (see ordering information below).
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Oas1a Antibody (E-2) is a mouse monoclonal IgG2a kappa light chain antibody that detects Oas1a in mouse and rat samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Oas1a (E-2) antibody is available in both non-conjugated and multiple conjugated forms, such as agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and various Alexa Fluor® conjugates. Oas1a, a member of the 2′-, 5′-oligoadenylate synthetase family, plays a crucial role in the cellular response to viral infections by synthesizing 2′-, 5′-oligomers of adenosine, which are essential for activating the latent RNase L enzyme. This activation leads to the degradation of single-stranded RNA, effectively inhibiting protein synthesis and viral replication, thereby contributing to the host′s antiviral defense mechanisms. Oas1a functions as a homotetramer and is composed of 400 amino acids, making Oas1a a significant player in the interferon response and a potential biomarker for conditions such as diabetes mellitus. As one of the rodent homologs of human OAS1, Oas1a is vital for understanding the mechanisms of cell growth, differentiation, and apoptosis, as well as the overall immune response to viral pathogens.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Oas1a Antibody (E-2) References:
- A specific isozyme of 2'-5' oligoadenylate synthetase is a dual function proapoptotic protein of the Bcl-2 family. | Ghosh, A., et al. 2001. J Biol Chem. 276: 25447-55. PMID: 11323417
- Characterization of the 2'-5'-oligoadenylate synthetase ubiquitin-like family. | Eskildsen, S., et al. 2003. Nucleic Acids Res. 31: 3166-73. PMID: 12799444
- Variation in antiviral 2',5'-oligoadenylate synthetase (2'5'AS) enzyme activity is controlled by a single-nucleotide polymorphism at a splice-acceptor site in the OAS1 gene. | Bonnevie-Nielsen, V., et al. 2005. Am J Hum Genet. 76: 623-33. PMID: 15732009
- Polymorphisms of interferon-inducible genes OAS-1 and MxA associated with SARS in the Vietnamese population. | Hamano, E., et al. 2005. Biochem Biophys Res Commun. 329: 1234-9. PMID: 15766558
- OAS1 splice site polymorphism controlling antiviral enzyme activity influences susceptibility to type 1 diabetes. | Field, LL., et al. 2005. Diabetes. 54: 1588-91. PMID: 15855350
- Enhancing and confirming the specificity of RNAi experiments. | Cullen, BR. 2006. Nat Methods. 3: 677-81. PMID: 16929311
- Structure of two forms of the interferon-induced (2'-5') oligo A synthetase of human cells based on cDNAs and gene sequences. | Benech, P., et al. 1985. EMBO J. 4: 2249-56. PMID: 2416561
- Induction of 2.5 OAS gene expression and activity is not sufficient for IFN-gamma-induced neuroblastoma cell differentiation. | Corrias, MV., et al. 1995. Int J Cancer. 62: 223-9. PMID: 7622300
- The human 2',5'-oligoadenylate synthetase locus is composed of three distinct genes clustered on chromosome 12q24.2 encoding the 100-, 69-, and 40-kDa forms. | Hovnanian, A., et al. 1998. Genomics. 52: 267-77. PMID: 9790745
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Oas1a Antibody (E-2) | sc-365072 | 200 µg/ml | $322.00 | |||
Oas1a Antibody (E-2): m-IgG Fc BP-HRP Bundle | sc-525855 | 200 µg Ab; 10 µg BP | $361.00 | |||
Oas1a Antibody (E-2): m-IgG2a BP-HRP Bundle | sc-546442 | 200 µg Ab; 10 µg BP | $361.00 | |||
Oas1a Antibody (E-2) X | sc-365072 X | 200 µg/0.1 ml | $322.00 | |||
Oas1a Antibody (E-2) AC | sc-365072 AC | 500 µg/ml, 25% agarose | $424.00 | |||
Oas1a Antibody (E-2) HRP | sc-365072 HRP | 200 µg/ml | $322.00 | |||
Oas1a Antibody (E-2) FITC | sc-365072 FITC | 200 µg/ml | $336.00 | |||
Oas1a Antibody (E-2) PE | sc-365072 PE | 200 µg/ml | $349.00 | |||
Oas1a Antibody (E-2) Alexa Fluor® 488 | sc-365072 AF488 | 200 µg/ml | $364.00 | |||
Oas1a Antibody (E-2) Alexa Fluor® 546 | sc-365072 AF546 | 200 µg/ml | $364.00 | |||
Oas1a Antibody (E-2) Alexa Fluor® 594 | sc-365072 AF594 | 200 µg/ml | $364.00 | |||
Oas1a Antibody (E-2) Alexa Fluor® 647 | sc-365072 AF647 | 200 µg/ml | $364.00 | |||
Oas1a Antibody (E-2) Alexa Fluor® 680 | sc-365072 AF680 | 200 µg/ml | $364.00 | |||
Oas1a Antibody (E-2) Alexa Fluor® 790 | sc-365072 AF790 | 200 µg/ml | $364.00 |