O-GlcNAc transferase Antibody (C-10): sc-376253
- O-GlcNAc transferase Antibody (C-10) is a mouse monoclonal IgG2a λ, cited in 1 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 927-961 within an internal region of O-GlcNAc transferase of human origin
- recommended for detection of O-GlcNAc transferase of mouse, rat, human and origin by WB, IP, IF, IHC(P) and ELISA; also reactive with additional species, including and equine, canine, bovine, porcine and avian
- See O-GlcNAc transferase (F-12): sc-74546 for O-GlcNAc transferase antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgGλ BP-HRP (mouse IgGλ binding protein-HRP) is the preferred secondary detection reagent for O-GlcNAc transferase Antibody (C-10) for WB and IHC(P) applications. This reagent is now offered in a bundle with O-GlcNAc transferase Antibody (C-10) (see ordering information below). For additional m-IgGλ BP conjugates see our complete list of Mouse IgG Binding Proteins.
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O-GlcNAc transferase Antibody (C-10) is a mouse monoclonal IgG2a antibody that detects O-GlcNAc transferase in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). O-GlcNAc transferase plays a crucial role in cellular signaling by catalyzing the addition of a single N-acetylglucosamine moiety to serine or threonine residues, a process that can influence protein function and stability. This modification is particularly important as it competes with phosphorylation for the same residues, thereby modulating the activity of numerous proteins involved in critical cellular processes such as transcription, cell cycle regulation, and stress responses. O-GlcNAc transferase is predominantly localized in the nucleus and cytosol, which is significant because such presence in these compartments suggests a direct involvement in regulating nuclear functions and cytoplasmic signaling pathways. Notably, O-GlcNAc transferase is expressed in various human tissues, with the pancreas showing the highest levels, indicating a potential role in metabolic regulation. O-GlcNAc transferase (C-10) antibody has been validated for use in multiple experimental settings, making this reagent an essential tool for researchers studying the dynamics of glycosylation and its implications in health and disease.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
O-GlcNAc transferase Antibody (C-10) | sc-376253 | 200 µg/ml | $322.00 | |||
O-GlcNAc transferase Antibody (C-10): m-IgGλ BP-HRP Bundle | sc-522895 | 200 µg Ab, 40 µg BP | $361.00 | |||
O-GlcNAc transferase (C-10) Neutralizing Peptide | sc-376253 P | 100 µg/0.5 ml | $69.00 |