NURIM Antibody (B-1): sc-390174

NURIM Antibody (B-1) is a mouse monoclonal IgG1 antibody that detects NURIM in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). NURIM, also known as NRM or NRM29, is a 262 amino acid multi-pass membrane protein primarily localized to the inner membrane of the nucleus, where NURIM plays a crucial role in maintaining nuclear envelope dynamics. NURIM exists in multiple alternatively spliced isoforms, which may contribute to diverse enzymatic functions. Understanding NURIM localization is vital, as NURIM is implicated in various cellular processes, including gene expression regulation and nuclear integrity maintenance. The gene encoding NURIM is located on human chromosome 6, a region associated with several significant health conditions, including early onset intestinal cancer and various neuropsychiatric disorders. The deletion of a portion of the q arm of chromosome 6 has been linked to a cancer susceptibility locus, highlighting NURIM′s importance in potential disease mechanisms. With NURIM′s ability to interact with other proteins involved in nuclear functions, anti-NURIM antibody (B-1) serves as a valuable tool for researchers investigating the complexities of nuclear biology and its implications in health and disease.

The preferred NURIM antibody is NURIM Antibody (E-11): sc-514010.