Nup93 Antibody (3332C2a): sc-81343
- Nup93 Antibody (3332C2a) is a mouse monoclonal IgG1, cited in 2 publications, provided at 100 µg/ml
- raised against a recombinant protein corresponding to an internal region of Nup93 of human origin
- recommended for detection of Nup93 of mouse, rat and human origin by WB and IP
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Nup93 Antibody (3332C2a). This work is in progress.
Nup93 Antibody (3332C2a) is a mouse monoclonal IgG1 antibody that detects Nup93 in mouse, rat, and human samples through applications such as western blotting (WB) and immunoprecipitation (IP). Nup93, a critical component of the nuclear pore complex (NPC), plays a vital role in mediating the transport of macromolecules between the nucleus and cytoplasm, which is essential for maintaining cellular homeostasis and regulating gene expression. Nup93 is predominantly located on the nuclear side of the NPC, particularly within the basket terminal ring area, where Nup93 forms a complex with other nucleoporins, including Nup188, Nup53, and Nup205. Nup93′s interaction with the Nup62 complex at the center of the NPC is crucial for the structural integrity and proper assembly of the nuclear pore, ensuring efficient transport processes. Structurally, Nup93 features a coiled-coil domain at its N-terminus and a C-terminal helical domain, which are important for its interactions and stability within the NPC. Proper functioning of Nup93 is essential for cell viability, as disruptions in Nup93′s activity can lead to impaired nucleocytoplasmic transport and various cellular dysfunctions.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Nup93 Antibody (3332C2a) References:
- HOXA repression is mediated by nucleoporin Nup93 assisted by its interactors Nup188 and Nup205. | Labade, AS., et al. 2016. Epigenetics Chromatin. 9: 54. PMID: 27980680
- Host Factor Nucleoporin 93 Is Involved in the Nuclear Export of Influenza Virus RNA. | Furusawa, Y., et al. 2018. Front Microbiol. 9: 1675. PMID: 30087672
- In Vivo Expression of NUP93 and Its Alteration by NUP93 Mutations Causing Focal Segmental Glomerulosclerosis. | Hashimoto, T., et al. 2019. Kidney Int Rep. 4: 1312-1322. PMID: 31517150
- Identification of nucleoporin 93 (Nup93) that mediates antiviral innate immune responses. | Monwan, W., et al. 2020. Biochem Biophys Res Commun. 521: 1077-1082. PMID: 31733835
- Nup93 regulates breast tumor growth by modulating cell proliferation and actin cytoskeleton remodeling. | Bersini, S., et al. 2020. Life Sci Alliance. 3: PMID: 31959624
- Nup93 and CTCF modulate spatiotemporal dynamics and function of the HOXA gene locus during differentiation. | Labade, AS., et al. 2021. J Cell Sci. 134: PMID: 34746948
- Nucleoporin 93 mediates β-catenin nuclear import to promote hepatocellular carcinoma progression and metastasis. | Lin, CS., et al. 2022. Cancer Lett. 526: 236-247. PMID: 34767927
- Nucleoporin-93 reveals a common feature of aggressive breast cancers: robust nucleocytoplasmic transport of transcription factors. | Nataraj, NB., et al. 2022. Cell Rep. 38: 110418. PMID: 35196484
- Nucleoporin 93, a new substrate of the E3 ubiquitin protein ligase HECTD1, promotes esophageal squamous cell carcinoma progression. | Zhang, J., et al. 2024. Hum Cell. 37: 245-257. PMID: 37993750
- Nucleoporin 93 Regulates Cancer Cell Growth and Stemness in Bladder Cancer via Wnt/β-Catenin Signaling. | Wang, Z., et al. 2024. Mol Biotechnol.. PMID: 38744786
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Nup93 Antibody (3332C2a) | sc-81343 | 100 µg/ml | $333.00 |